青钱柳叶水提物对N_ω-硝基左旋精氨酸甲酯盐酸盐诱导的高血压大鼠的影响  

Effect of the Aqueous Extract from Cyclocarya paliurus on Hypertensive Rats Induced by Nω-nitro-L-arginine Methyl Ester Hydrochloride

作　　者：刘晓霞[1] 席加喜[1] 王硕[2] 张春花[3] 刘华钢[1] 缪剑华[1] 

机构地区：[1]广西医科大学药学院,南宁530021 [2]广西药用植物研究所,南宁530023 [3]广西中医学院药学院,南宁530001

出　　处：《中国实验方剂学杂志》2012年第8期174-178,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广西科学研究与技术开发计划项目(桂科攻0718006-3C)

摘　　要：目的:探讨青钱柳叶水提物对Nω-硝基左旋精氨酸甲酯盐酸盐(L-NAME,Nω-nitro-L-arginine methyl ester hydrochloride)诱导的高血压大鼠的影响。方法:用L-NAME ig给药4周复制高血压大鼠模型。将40只高血压大鼠随机分为模型组、青钱柳叶水提物低、中、高剂量组(3.0,6.0,12.0 g·kg-1.d-1)和卡托普利组(0.010 g·kg-1.d-1),每组8只。另外正常8只SD大鼠作为空白组。采用无创尾动脉测压法,每周测定大鼠血压1次,共6周。计算大鼠左心室质量指数和肾脏质量指数,观察胸主动脉形态学变化。结果:给予青钱柳叶水提物6周后,高血压大鼠的收缩压和舒张压明显降低(P<0.01或P<0.05),其中低、中、高剂量组的收缩压下降率分别为16.18%,16.92%,16.92%;舒张压下降率分别为15.98%,15.73%,16.64%。同时治疗组左心室质量指数和肾脏质量指数下降(P<0.01或P<0.05),能够缓和胸主动脉中膜增厚现象。结论:青钱柳叶水提物对L-NAME诱导的高血压大鼠血压有降低作用。Objective：To observe the effect of the aqueous extract from Cyclocarya paliurus on hypertensive rats induced by L-NAME（Nω-nitro-L-arginine methyl ester hydrochloride）.Method： Hypertensive rats were given by L-NAME for 4 weeks to produce hypertensive model.The 40 hypertensive rats were randomly divided into model group,C.paliurus extract low,medium and high dose group（3.0,6.0,12.0 g·kg-1）,captopril group（0.010 g·kg-1）,additional 8 rats were choose as control group.Non-invasive blood pressure measurement was used to detect the arterial blood pressure of rat tail once a week for 6 weeks.The left ventricular weight index and kidney weight index were calculated,and morphological changes of the thoracic aorta were observed.Result： After 6 weeks of administration,the systolic and diastolic blood pressure of hypertensive rats significantly decreased（P0.01,P0.05）,in low,medium and high-dose groups,the decreased systolic blood pressure rate was 16.18%,16.92%,16.92%;the decreased diastolic blood pressure rate was 15.98%,15.73%,16.64%.The treatment groups decreased left ventricular thickening and kidney weighting,and could moderate medial membrane thickening of the thoracic aorta.Conclusion： C.paliurus extract could reduce blood pressure in L-NAME induced hypertensive rats.

关 键 词：Nω-硝基左旋精氨酸甲酯盐酸盐 高血压大鼠 心肾指数 主动脉形态 

分 类 号：R285.5[医药卫生—中药学]