血管内皮功能障碍与动脉粥样硬化研究进展  

Research Progress of Endothelial Dysfunction and Atherosclerosis

作　　者：李丹[1] 李玉洁[1] 杨庆[1] 陈颖[1] 翁小刚[1] 邹丽娟[1] 朱晓新[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2012年第8期272-276,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：科技部重大新药创制综合性中药新药研究开发技术大平台项目(2009 ZX093 01-005-2-4);国家自然科学基金面上项目(30973901);国家直属科研院所技术开发研究专项资金(NCSTE-2007-JKZX-301);中国中医科学院自主选题项目(ZZ20090207)

摘　　要：对血管内皮功能障碍与动脉粥样硬化(atherosclerosis,As)的关系、治疗方法及中药通过调节血管内皮功能障碍治疗As的研究进行文献整理和分析。以血管舒缩、内皮功能障碍、As等为主题词进行文献检索,总结血管内皮功能障碍与As的关系及近10年来国内外治疗血管内皮功能障碍的研究进展。总结了动脉粥样硬化与血管内皮功能障碍之间的关系,调节血管内皮功能障碍从而治疗动脉粥样硬化的方法大致有保护内皮的天然物质替代疗法、内皮种植及基因治疗、补充外源性一氧化氮(NO)、拮抗内皮素(ET)等;并总结了中药单味药、中药复方通过调节血管内皮功能治疗As的研究进展。结果表明:血管内皮细胞分泌的血管舒缩物质如NO/ET与As关系的深入研究治疗是防治As发生和发展的重要研究方向。中药在保护内皮功能、调节内皮活性物质分泌方面具有显著作用,但发挥调节血管功能障碍药效的物质基础和作用机制研究缺乏深度,进一步探讨中药抗As的作用机制,发挥中药复方多靶点调节的优势,开发基于调节血管功能障碍的抗As的中药,在中医药防治心脑血管疾病研究领域具有广阔前景。This paper presented the reseach progress of the relationship between vascular endothelial dysfunction and atherosclerosis via literature review and analysis on therapeutic regulation on vascular endothedial dysfunction for treatment of atherosclerosis using traditional Chinese medicine.Through the keywords of vasomotor,endothelial dysfunction,atherosclerosis,etc.thirty eight literature introducing the relationship between endothelial dysfunction and atherosclerosis,and summing up the research progress of treatment of endothelial dysfunction in the recent decade was collected and reviewed.The methods of treating atherosclerosis through regulating vascular endothelial dysfunction were summarized generally as the complementary therapy of natural substances for restoration of endothelial function,endothelial plantation and gene therapy,exogenous nitric oxide（NO）,endothelin antagonists,etc.;the progress on treating atherosclerosis through regulating NO and endothelin（ET） using Chinese single herb and formulas was presented.The results show that the methods of regulating the vascular endothelial dysfunction were diversified,the further study on the relationship between atherosclerosis and vasomotor substances such as NO/ET is the important research direction.The traditional Chinese medicine has significant role in the protection of endothelial dysfunction andregulating the endothelial secretion of active substances,but it lacks the depth on the material basis and mechanism that regulating vascular dysfunction,efficacy,so it will has broad prospects in the fields of preventing and treating cardiovascular disease to further explore the anti-atherosclerotic mechanisms of traditional Chinese medicine,playing the advantages of multi-target regulation of Chinese herbal compound,developing the anti-atherosclerosis traditional Chinese medicine based on the regulation of vascular dysfunction.

关 键 词：内皮功能障碍 动脉粥样硬化 一氧化氮 内皮素 

分 类 号：R285.5[医药卫生—中药学]