光纤传感技术对盐酸普萘洛尔片快速分析方法学建立  

Establishment of rapid fiber optic sensor analysis method about propranolol hydrochloride tablets

作　　者：冯翠娟[1] 李莉[1] 张春玲[1] 靳露[1] 杨婷[1] 

机构地区：[1]新疆医科大学药学院,乌鲁木齐830011

出　　处：《药物分析杂志》2012年第4期701-705,共5页Chinese Journal of Pharmaceutical Analysis

基　　金：国家自然科学基金(30960365)

摘　　要：目的:建立光纤传感快速分析盐酸普萘洛尔片的方法,并进行定性、定量分析。方法:采用光纤传感分析技术对盐酸普萘洛尔片进行紫外吸收光谱鉴定和含量测定。探头直接浸入药品溶液,进行数据采集,通过计算机自动处理数据,测得药物含量。同时与中国药典(二部)2010年版收载的含量测定方法进行测定比较。结果:本法测定不需过滤辅料,样品处理方法简单,可瞬间获得片剂的特征图谱,提取相关参数;含量测定结果与药典方法比较无显著性差异(P>0.05)。结论:光纤传感分析法可用于快速、准确对盐酸普萘洛尔片进行定性定量分析。Objective：To develop a method that can analyze Propranolol Hydrochloride tablets by fiber optic sensor rapidly,and determine the spectrum and content of Propranolol Hydrochloride tablets.Methods：using fiber-optical sensing technology to determine the ultraviolet absorption spectrum and content of Propranolol Hydrochloride,the detector end was dipped into the original solution of the Propranolol Hydrochloride tablets directly,when information related to the samples was imported into the computer,it can show the scanning map and provide drug content.And compared the consistency of this method with the method in ChP（2010） in regard to determination at the same time.Results：The method can be instantaneous access to the feature map of the Propranolol Hydrochloride tablets and obtain the related parameters.The determination results obtained by this method had no significant difference compared with the method in ChP（2010）（P0.05）.Conclusion：The method of analysis by fiber optic sensor can be used for rapid analysis for Propranolol Hydrochloride tablets.

关 键 词：盐酸普萘洛尔(心得安) 光纤传感分析法 快速分析 紫外分光光度法 光导纤维 光纤探头 二极管阵列电荷耦合器件中 

分 类 号：R917[医药卫生—药物分析学]