149例IgA肾病合并高尿酸血症的临床和病理特点  

Clinical and pathological characteristics of IgA nephropathy patients with hyperuricemia

作　　者：田耘[1,2] 卓莉[1] 李文歌[1] 邹古明[1] 芦建华[1] 

机构地区：[1]卫生部中日友好医院肾内科,北京100029 [2]陕西省中医医院肾病科

出　　处：《北京医学》2012年第4期257-259,共3页Beijing Medical Journal

摘　　要：目的探讨IgA肾病合并高尿酸血症患者的临床和病理特点,并分析其相关因素。方法对2009-2010年卫生部中日友好医院经肾活检确诊为IgA肾病的311例患者的临床和病理资料进行回顾分析。依据血尿酸水平,将IgA肾病患者分为血尿酸正常组与高尿酸血症组,对比分析2组患者临床和病理特点。结果 IgA肾病患者中高尿酸血症的患病率为47.9%;与血尿酸正常组比较,高尿酸血症患者在性别、24h尿蛋白定量[血尿酸正常组(2.2±2.1)g/d,高尿酸血症组(2.7±2.5)g/d,P<0.05]、肾功能水平[血尿酸正常组血清肌酐(83.3±40.1)μmol/L,高尿酸血症组(142.2±114.5)μmol/L,P<0.01]以及高血压、肥胖、肾脏病理损伤程度等方面的差异均有统计学意义。结论 IgA肾病患者高尿酸血症的患病率高,与尿酸正常患者比较,临床表现和肾脏病理损伤多较重,提示高尿酸血症可能与患者预后相关。Objective To investigate the clinical and pathological characteristics of IgA nephropathy patients with hyperuricemia. Methods Three hundreds and eleven IgA nephropathy patients confirmed by renal biopsy from January 2009 to January 2010 were analyzed retrospectively. The patients were divided into the two groups： IgA nephropathy patients with or without hyperuricemia. A comparative analysis of clinical manifestations and renal pathological injuries was performed between the two groups. Results The prevalence rate of hyperuricemia in IgA nephropathy patients was 47.9%. There were remarkable differences between the two groups in the ratio of male gender, 24-hour urine protein level, kidney function levels, hypertension, obesity and renal pathological injuries. Conclusions The prevalence of hyperuricemia in IgA nephropathy patients is high. Clinical manifestations and renal pathological lesions in IgA nephropathy patients with hyperuricemia are more severe compared to those with normal serum uric acid level.

关 键 词：IGA 肾病 高尿酸血症 肾脏病理 预后 

分 类 号：R692.3[医药卫生—泌尿科学]