碳糊电极阳极吸附伏安法测定卡托普利  

Anodic Adsorptive Voltammetric Determination of Captopril at a Carbon Paste Electrode

作　　者：易伟[1,2] 易兰花[1] 费俊杰[1] 黎拒难[1] 

机构地区：[1]湘潭大学化学学院,环境友好化学与应用省部共建教育部重点实验室,湖南湘潭411105 [2]湘潭大学兴湘学院,湖南湘潭411105

出　　处：《分析科学学报》2012年第2期230-232,共3页Journal of Analytical Science

基　　金：湖南省科技计划(No.2010GK3181);湘潭大学自然科学基金(No.10XZX07);湖南省大学生创新性实验计划资助项目

摘　　要：在0.40 mol/L的HAc-NaAc(pH=4.8)缓冲溶液中,卡托普利(Captopril,CPT)在碳糊电极(CPE)上有一灵敏的吸附氧化峰,峰电位为0.23 V(vs.SCE)。该氧化峰的二阶导数峰电流与卡托普利的浓度在2.0×10-8～1.0×10-6mol/L(富集90 s)范围内呈良好的线性关系,相关系数为0.9966,检出限为8.0×10-9mol/L,并成功应用于卡托普利片含量的测定。探讨了卡托普利在碳糊电极上的伏安性质和电极反应机理。A highly selective and rapid anodic adsorptive voltammetric method has been developed for the determination of trace amount of captopril at a carbon paste electrode（CPE）in the current paper.Captopril is adsorbed on the surface of the CPE in 0.40 mol/L HAc-NaAc buffer solution（pH=4.8）,yielding one oxidation peak at 0.23 V（vs.SCE）.The relationship between the peak current and captopril concentration is linear in the range of 2.0×10-8~1.0×10-6 mol/L with the correlation coefficient of 0.9966.The detection limit is 8.0×10-9 mol/L（S/N=3） for 90 s acummulation.The proposed method was applied to the direct determination of captopril in the captopril tablet with satisfactory results and the electrode reaction mechanism of captopril was investigated.

关 键 词：卡托普利 阳极吸附伏安法 碳糊电极 

分 类 号：O657.14[理学—分析化学]