IL-6-174G／C及-572C／G基因多态性与2型糖尿病大血管病变的相关性、  

The association between C-174G,G-572C polymorphisms of interleukin-6(IL-6) gene and type 2 diabetic macrovascular diseases

作　　者：刘大娜[1,2] 郭敏[1] 徐莹[1] 姜晓艳[1] 

机构地区：[1]哈尔滨医科大学附属第一医院内分泌科,150001 [2]哈尔滨市第一医院

出　　处：《中国糖尿病杂志》2012年第4期259-262,共4页Chinese Journal of Diabetes

基　　金：黑龙江省科技攻关基金资助项目(GC05C40402)

摘　　要：目的观察IL-6基因启动子区-174G/C及-572C/G多态性在中国汉族人群中的分布频率与T2DM患者大血管病变(DVC)的遗传易感性的关系。方法应用聚合酶链反应-限制性片段长度多态性分析(PCR-RFLP)方法检测480例患者(DM组120例,DVC组160例,对照组200例)-174位点、-572位点多态性。结果 IL-6基因启动子区-174G/C多态性中,携带C等位基因的个体患DVC风险为G等位基因的1.8271倍(95%CI:1.1785～2.8327,P<0.01)。-572C/G多态性在DM+DVC组与对照组比较,差异无统计学意义(P>0.05)。结论 IL-6-174G/C基因多态性与DVC的发病具有相关性。C等位基因可能是DVC的遗传易感基因。Objective To study association between the polymorphisms in the promoter of interleukin-6 （IL-6） gene -174G/C and -572C/G macrovascular disease （MA） in type 2 diabetes mellitus （T2DM） in Chinese Han population. Methods Using the PCR-restriction fragment length polymorphism method, two IL-6 promoter polymorphism genes （-174G/C, -572C/G） were studied in 480 subjects including 120 diabetes without macrovascular disease, 160 diabetes with macrovascular disease and 200 controls. Results For -174G/C polymorphism in the promoter of IL-6 gene, the incidence of macrovascular disease in type 2 diabetes in the individuals with C allele was significantly increased in comparison with the carriers of G allele（OR= 1. 8271,95% CI： 1. 1785-2. 8327, P^0. 01）. There was no statistical difference between DM＋ DVC and control groups for -572C/G polymorphism. Conclusion These results suggest that the -174G/C polymorphism in the promoter of IL-6 gene is associated with macrovascular disease in type 2 diabetes. The C allele in -174G/C of IL-6 gene may contribute to the predisposition gene locus for macrovascular disease in type 2 diabetes.

关 键 词：白细胞介素-6 基因多态性 糖尿病 2型 C反应蛋白 大血管合并症 

分 类 号：R587.2[医药卫生—内分泌]