对比剂Gd-DTPA对肝外胆管癌磁共振扩散加权成像的影响  

The effect of using Gd-DTPA as contrast medium on diffusion weighted imaging for extrahepatic cholangiocarcinoma

作　　者：王余 王海平 韩德昌 马梦华 孙正君 

机构地区：[1]唐山市工人医院核磁共振室,河北063000

出　　处：《放射学实践》2012年第4期421-424,共4页Radiologic Practice

基　　金：2010年唐山市科学技术研究与发展计划指导项目(10130251a)

摘　　要：目的:探讨对比剂钆喷替酸葡甲胺(Gd-DTPA)对肝外胆管癌磁共振扩散加权成像(DWI)图像质量及表观扩散系数(ADC)的影响。方法:回顾性分析经病理证实并被DWI检出的57例肝外胆管癌患者的DWI图像资料,比较静脉注射对比剂Gd-DTPA增强前后及不同b值条件下肝外胆管癌病灶信噪比(SNR)、病灶与正常肝脏间对比信噪比(CNR)及ADC值的差异。结果:同一b值条件下,增强前后病灶SNR、CNR、ADC值的差异均无统计学意义(P>0.05);增强前后肝外胆管癌病灶SNR、CNR及ADC值均随着b值的增大而降低,其差异均有统计学意义(P<0.05)。结论:肝外胆管癌病灶的DWI图像质量及ADC值不受Gd-DTPA影响,所以选择合适b值的增强后DWI序列是可行的。Objective：To evaluate the effect of Gd-DTPA as contrast medium for the image quality and apparent diffusion coefficient（ADC） on diffusion weighted imaging（DWI） of extra hepatic cholangiocarcinoma.Methods：The DWI materials of 57 patients with extrahepatic cholangiocarcinoma confirmed by pathology were analyzed retrospectively.The differences of signal-noise ratio（SNR） of tumor foci,contrast-noise ratio（CNR） of tumor foci and normal liver,ADC values of extrahepatic cholangiocarcinoma before and after administration of Gd-DTPA with different b values were measured and compared.Results：Of the same b value,no statistical significant differences were existed on SNR and CNR and ADC values of tumor foci before and after administration of Gd-DTPA（P0.05）.As the b values increased,the SNR,CNR and ADC values of tumor foci before and after Gd-DTPA administration decreased gradually with significant statistical differences（P0.05）.Conclusion：The DWI quality and ADC values were not influenced by Gd-DTPA administration,it is feasible to choose appropriate b value to perform DWI after administration of Gd-DTPA for the diagnosis of extrahepatic cholangiocarcinoma.

关 键 词：胆管癌 扩散加权成像 钆喷替酸葡甲胺 

分 类 号：R445.2[医药卫生—影像医学与核医学] R735.8[医药卫生—诊断学]