Gd-BOPTA增强MRI肝胆期扫描最佳延迟时间的初步探讨  

Preliminary study of the optimal delay time for liver MR imaging enhanced with Gd-BOPTA

作　　者：阳琴[1] 唐鹤菡[1] 黄子星[1] 李昌宪[1] 陈宪[1] 宋彬[1] 

机构地区：[1]四川大学华西医院放射科,成都610041

出　　处：《放射学实践》2012年第4期425-428,共4页Radiologic Practice

基　　金：国家自然科学基金资助项目(81171338)

摘　　要：目的:采用对比剂钆贝葡胺(Gd-BOPTA)对肝功能正常志愿者行增强MRI肝胆期扫描,评价不同延迟时相肝实质、胆道系统的信号变化,探讨肝脏功能正常时肝胆期最佳延迟时间的选择。方法:应用对比剂Gd-BOPTA并采用容积式内插值法屏气检查(VIBE)轴面T1WI序列对48例无肝胆疾病的志愿者分别于注射对比剂后40、60和90min行肝胆期扫描,测量并比较各时相肝脏、左右肝管、胆囊和胆总管的信噪比(SNR),对比率(CR),SNR增长率和CR增长率。结果:全肝、左肝管的SNR和CR均在注射Gd-BOPTA后60min达到峰值,而胆囊和胆总管在延迟90min时达到峰值(P<0.05);胆囊SNR增长率和CR增长率及胆总管SNR增长率在延迟90min时达到峰值(P<0.05)。结论:正常肝功能者行Gd-BOPTA增强MRI扫描,可在延迟60min时获得肝脏和左右肝管强化的最佳图像,延迟90min时获得胆囊和胆总管强化的最佳图像。Objective：Using enhanced abdomen MRI with Gd-BOPTA in volunteers with normal liver function to evaluate the changes of signal intensities of hepatic parenchyma and biliary system in various delay time period in order to choose the optimal delay time of hepatic-biliary system in subjects with normal liver function.Methods：Forty-eight volunteers with no hepatic-biliary disease received abdomen MRI enhanced by Gd-BOPTA with volumetric interpolated breath-hold sequence,the hepatic-biliary system was studied 40,60 and 90min after enhancement.The SNR,CR,SNR growth rate and CR growth rate of liver parenchyma,left and right bile ducts,gall bladder and common bile duce at different time points were measured and compared.Results：The SNRs and CRs of liver parenchyma and left hepatic duct reached their peaks at 60min after enhancement,while the SNRs and CRs of gallbladder and common bile duct reached their peaks at 90min after enhancement（P0.05）;The SNR growth rate and CR growth rate of gallbladder and the SNR growth rate of common bile duct reached their peaks at 90min after enhancement（P0.05）.Conclusion：For individuals with normal liver function,the optimal delay time to obtain the best image of liver and left/right hepatic ducts after receiving Gd-BOPTA enhancement was 60min,while 90min was the optimal time to obtain the best display of gallbladder and common bile duct.

关 键 词：磁共振成像 钆贝葡胺 延迟时间 肝胆期 

分 类 号：R445.2[医药卫生—影像医学与核医学] R575[医药卫生—诊断学]