EV71感染抗病毒药物及疫苗研究进展  

Developments towards antiviral agents and vaccine against enterovirus 71

作　　者：张迎秋[1] 杨怀义[2] 杨倬[2] 时迎娣[2] 赵春晖[1] 

机构地区：[1]辽宁师范大学生命科学学院,辽宁大连116029 [2]中国科学院微生物研究所病原微生物与免疫学重点实验室,北京100101

出　　处：《微生物学通报》2012年第4期544-552,共9页Microbiology China

基　　金：国家自然科学基金项目(No.21102067)

摘　　要：手足口病在世界多个地区,尤其是亚洲爆发并流行,且其感染率和死亡率逐年增高,危害十分严重。肠道病毒71(Enterovirus 71,EV71)是手足口病(Hand,foot,andmouth disease,HFMD)的主要病原体,以感染婴幼儿为主,其感染常伴随神经系统并发症,严重可导致儿童死亡。近年来,分子生物学和抗病毒研究方面取得的进展为EV71感染的预防及治疗提供了新的途径。本文对EV71病毒学特点及抗EV71药物的筛选、疫苗开发、RNA干扰等进行了综述,以期为相关研究提供参考。Hand,foot,and mouth disease（HFMD） outbreaks have been reported in many ar-eas,especially in Aria.Enterovirus 71（EV71） is the major causative pathogen of HFMD in children and infants,its infection usually accompanied with severe neurological complication which causes high mortality.In recent years,the molecular biology study of EV71 and the progress of antiviral therapies development provide us new strategies for the treatment and prevention of EV71 infection.This paper reviewed the latest achievements in virology and an-tiviral agents of EV71,including drugs,vaccine,and RNA interference etc,which may be ex-pected to serve as references for related research.

关 键 词：肠道病毒71型 抗病毒药物 疫苗 RNA干扰 

分 类 号：R392.1[医药卫生—免疫学]