血液灌流对口服泰诺中毒患者血清中主要药物成分的清除效果  

Study on the effect using hemoperfusion to treat tylenol poisoned patients

作　　者：赖登攀[1] 任晓华[1] 姚菊平[1] 刘茂林[1] 徐刚[1] 陈兆军[1] 冷贵兰[1] 

机构地区：[1]杭州师范大学附属医院杭州市第二人民医院急诊科,310015

出　　处：《中华劳动卫生职业病杂志》2012年第4期310-312,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：浙江医药卫生科技计划（2005A087）;杭州市科学技术计划项目（20061133814）;浙江省科技支撑和引导项目（2007C33009）

摘　　要：目的评价血液灌流（hemoperfusion，HP）清除口服泰诺中毒患者血清中泰诺主要成分的效果。方法采用股静脉插管急诊建立血液通路，利用血泵为动力、炭肾为吸附剂对2例急性泰诺中毒患者进行HP治疗，并动态观察血清中乙酰氨基酚等药物成分浓度的变化，测定血液灌流器（炭肾）中所吸附的泰诺主要成分的吸附量。结果HP治疗能使患者体内的泰诺有效成分快速下降，病例1血清中对乙酰氨基酚浓度从HP开始前的13．4μg／L降为HP结束时的5．81μg／L；病例2血清中对乙酰氨基酚浓度别从HP开始前的51．1μg／L降为HP结束时的22．3μg／L。病例1的炭肾对乙氨基酚的吸附量为119542μg，病例2为332154μg。结论HP能在短时间内有效降低口服泰诺中毒患者体内的泰诺主要成分的含量，HP治疗急性泰诺中毒有效。Objective To explore the effect of hemoperfusion （HP） on tylenol poisoned patients. Methods Urgently established the blood access by transfemoral catheterization of femoral vein, we used charcoal hemoperfusion by blood pump and dynamically monitored the plasma concentration of tylenol activingredients for the 2 patients and the content of tylenol activingredients in the charcoal was determined. Results Plasma concentration of tyleuol activingredients of the 2 patients was declined gradually during and after the HP management. The acetaminophen serum concentration of the case 1 was declined from thel3.4μg/L at the start of HP to the 5.81 μg/L at the end of HP;and the case 2 was declined from 51.1μg/L to 22.3 μg/L. The adsorption amount of acetaminophen in the blood perfusion device are respectively 119 542 μg of case 1 and 33 2154 μg of case 2. Conclusion Early hemoperfusion should be carried out for acute tylenol poisoning patients if there were indications, hemoperfusion can clear the tylenol activingredients and this is an effective measure to eliminate tylenol activingredients

关 键 词：灌流 中毒 治疗结果 

分 类 号：R595.4[医药卫生—内科学] R459.5[医药卫生—临床医学]