红北柴胡药效作用初探  

Pharmacodynamics of Bupleurum Chinese DC.and B.Scorzonerifolium Willd

作　　者：刘晓节[1,2] 胡杰[1,2] 张福生[2] 李震宇[2] 秦雪梅[1,2] 

机构地区：[1]山西大学化学化工学院,太原山西030006 [2]山西大学中医药现代研究中心,太原山西030006

出　　处：《辽宁中医杂志》2012年第4期712-714,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(31070295);国家自然科学基金(30570174);山西省自然基金(20051085)

摘　　要：目的:比较研究北柴胡和红柴胡在解热、抗炎、镇痛及保肝等方面药效作用间的差异。方法:wistar大鼠和昆明种小鼠随即分为5组正常组、模型组、北柴胡组、红柴胡组和阳性对照组,分别采用大鼠2,4-二硝基苯酚致热实验、小鼠光热法致尾痛实验、小鼠腹腔毛细血管通透性实验及四氯化碳所致小鼠急性肝损伤实验进行药效评价与验证。结果:结果表明,北柴胡的抗炎、镇痛作用比红柴胡好,而红柴胡的解热作用优于北柴胡。结论:中药的品种对其疗效会产生很重要的影响,建议在临床用药时北柴胡和红柴胡不可混用,应注明其品种,以确保中药疗效的稳定性。Objective：To study the differences of pharmacological effects between B.Scorzonerifolium DC.and B.Scorzonerifolium Willd.including analgesic,antipyretic effect,anti-inflammatory and hepatoprotective effects.Methods：thermogenic action induced by 2,4-dinitrophenol,tail-pain test by photothermy and vinegar abdominal capillary permeability were applied to evaluate and validate the pharmacodynamics of B.chinense DC.and B.scozonerifolium Willd.Five groups in each experiment,heath control group,model group,positive control group,B.chinense DC.group and B.scozonerifolium Willd.group.Results：The anti-inflammatory and analgesic effect of B.chinense DC.group were better than B.scozonerifolium Willd.group,which,however,had the better antipyretic effect.Conclusion：Because varieties of traditional Chinese medicine have important effects on its therapy and in order to ensure the therapy stability of traditional Chinese medicine,it is recommended that B.chinense DC.and B.scozonerifolium Willd.should be used respectively on clinical application.

关 键 词：药效 北柴胡 红柴胡 

分 类 号：R285.5[医药卫生—中药学]