TRIB3基因＋251A／G多态性与高血压患者颈动脉粥样硬化的关系  

Association of TRIB3 gene ＋ 251A/G polymorphism with carotid atherosclerosis in hypertensive patients

作　　者：董春玉[1] 刘英晓[1] 赵秀萍[1] 宋春雨[1] 鞠卫萍[1] 郑谊梅[1] 郝军[1] 李振光[1] 

机构地区：[1]潍坊医学院附属文登中心医院神经内科,威海264400

出　　处：《国际遗传学杂志》2012年第2期65-69,共5页International Journal of Genetics

基　　金：威海市科技局资助项目（2009-3-88-1）

摘　　要：目的探讨TRIB3基因多态性与颈动脉粥样硬化的关系及可能的机制。方法采用彩色多普勒超声诊断仪及聚合酶链式反应-限制性片段长度多态性（polymerasechainreaction—restrictivefragmentlengthpolymorphism，PCR—RFLP）法对随机选取高血压患者200例，正常对照200例进行检测。结果与对照组相比，高血压组平均内膜一中层厚度（intima．mesathickness，IMT）明显升高（t=39．223，P〈0．01）；与从基因型携带者相比，GG基因型携带者平均IMT增大（t=22．235，P〈0．001）；IMT增厚危险因素Logistic回归分析，AG＋GG基因型进入回归方程（OR=2．116，95％CI：1．045～4．721，P=0．031），腰围、收缩压和空腹血糖升高是IMT增厚的危险因素。结论携带TRIB3基因＋251A／G多态性G等位基因的高血压患者具有颈动脉粥样硬化的易患性。Objective To investigate the effect of TRIB3 gene polymorphism on carotid athero- sclerosis in hypertensive patients. Methods A total of 400 subjects were recruited in the study including control group （ n = 200 ） and hypertension group （ n = 200 ）. These 400 subjects were genotyped using polymerase chain reaction-restrictive fragment length polymorphism （PCR-RFLP）. All of them underwent earoiid ultrasonography. Results Compared to the eontrols, the hypertensive patients showed increased IMT （ t = 39.223 , P 〈 0.01 ） ; The GG allele carriers had more thickened IMT than the AA allele car- riers （t = 22. 235 ,P 〈 0. 001 ） ; The Logistic regression analysis suggested that the Gallele is the risk factors for carotid atheroselerosis （OR =2. 116, 95% CI：1.045 4. 721, P =0.031）. Furthermore, waist circumference, systolic blood pressure and fasting blood glucose are risk factors for thickened IMT. Conclusion Those hypertensive patients carrying TRIB3 gene ＋ 251A/G polymorphism G allele were susceptible to carotid atherosclerosis

关 键 词：高血压 颈动脉粥样硬化 TRIB3 多态性 

分 类 号：R544.1[医药卫生—心血管疾病]