氧化应激在肝纤维化发展过程中的作用  

Effect of Oxidative stress on liver fibrosis

作　　者：李丰衣[1] 张琳[2,3] 聂为民[1] 

机构地区：[1]解放军第三0二医院感染性疾病诊疗与研究中心,北京100039 [2]解放军第三0二医院全军中药研究所,北京100039 [3]成都中医药大学,四川成都610075

出　　处：《中华中医药学刊》2012年第4期720-722,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家"十一五"重大科技专项资助项目(2008ZX10005-008);山东省自然科学基金青年基金资助项目(Q2005C04)

摘　　要：肝纤维化是各种原因所致的肝损伤在组织修复过程中的一种代偿反应,以细胞外基质过量沉积为病理特征。诸多肝损伤因素在其致病过程中均不同程度地伴有氧化应激,这些病因不祛除、长期作用于肝脏即可导致肝纤维化乃至肝硬化。近年来,氧化应激与肝纤维化,特别是肝星状细胞活化的关系日益受到关注。就氧化应激在肝纤维化发生、发展中的作用机制作一综述。Liver fibrosis was a compensation reaction,characterized by mass ECM deposition,coming from the reparative process of live tissue when the live was injured by various reasons.In the pathogenic course,oxidative stress was involved in a different degree which would lead to hepatic fibrosis,even cirrhosis,if long affected the liver and could not been eliminated.In recent years,the relationship between the oxidative stress and hepatic fibrosis,especially and the activated HSC,has been paid much more attention.The article summarized the mechanism how oxidative stress affected the occurrence and development of liver fibrosis.

关 键 词：氧化应激 肝纤维化 肝星状细胞 活性氧 

分 类 号：R657.31[医药卫生—外科学]