超声心动图评价自发性高血压大鼠左室舒张功能的可行性研究  

Evaluation of Cardiac Diastolic Function in Spontaneously Hypertensive Rats by High-Resolution Echocardiography

作　　者：付明强[1] 周京敏[1] 钱菊英[1] 钟春林[1] 许剑峰[1] 邹云增[1] 葛均波[1] 

机构地区：[1]上海市心血管病研究所复旦大学附属中山医院心内科,上海市200032

出　　处：《中国超声医学杂志》2012年第4期300-303,共4页Chinese Journal of Ultrasound in Medicine

基　　金：国家十一五科技支撑计划(No.2006BAI01A04);国家自然科学基金面上项目(No.81070105)

摘　　要：目的利用超声心动图评价自发性高血压大鼠(SHR)左室舒张功能。方法 15只3月龄雄性SHR,每3个月观测1次至9月龄,以同月龄Wistar大鼠15只作为对照。采用17.5 MHz小动物高频超声探头,通过M型超声、二尖瓣血流频谱和组织多普勒技术评价两组动物心脏结构与舒张功能各项指标变化。结果和Wistar大鼠相比,3月龄SHR即出现E/E'升高(P<0.01);6月龄和9月龄SHR E/A、E'/A'均小于同月龄Wistar大鼠值(P<0.05),E/E'均大于同月龄Wistar大鼠值(P<0.01);减速时间(DT)、等容舒张时间(IVRT)比较差异无统计学意义。6月龄和9月龄SHR E/A、E'/A'均小于3月龄SHR值(P<0.05);E/E'均大于3月龄SHR值(P<0.05);DT、IVRT变化差异无统计学意义。不同月龄Wistar大鼠各项舒张功能超声指标变化差异无统计学意义。SHR和Wistar大鼠随月龄增大收缩功能变化差异均无统计学意义。结论 E/A、E'/A'和E/E'是评价SHR舒张功能变化的敏感指标。Objective To investigate the feasibility of high resolution echocardiography in evaluation of cardiac diastolic function in spontaneously hypertensive rats （SHR）. Methods Three-month-old male SHR （n = 15） were used and followed until 9 months old at intervals of 3 months, Wistar rats of the same age （n=15） served as controls. Comprehensive echocardiographic parameters of cardiac structure and function were obtained through M-mode, Pulsed- wave Doppler and Tissue Doppler imaging with a 17.5 MHz probe. Results Compared with Wistar rats, three-month-old SHR demonstrated an elevation of E/E＇ （P〈0.01） while SHR at six months and 9 months exhibited sub stantial decreased E/A and E＇/A＇ together with increased E/E＇ （all P〈0. 05）. There were no statistical differences pertaining to deceleration time （DT） and isovolumic relaxation time （IVRT） between SHR and Wistar rats among each age group. And E/A, E＇/A＇ decreased while E/E＇ increased for SHR of 6 months and 9 months when compared to the values of 3-months-old SHR. No difference of diastolic parameters was found in Wistar rats. Systolic function assessed by left ventricular ejection fraction （LVEF） and fractional shortening （FS） both remained unchanged for SHR and Wistar rats. Conclusions High-resolution echocardiography is a powerful tool to assess cardiac diastolic function in SHR, E/A, E＇/A＇ and E/E＇ are the most valuable indices.

关 键 词：高频 超声心动描记术 自发性高血压大鼠 舒张功能 

分 类 号：R540.45[医药卫生—心血管疾病] R544.1[医药卫生—内科学]