大鲵低聚糖肽对小鼠免疫功能调节作用的研究  

Regulation of glycopetides of giant salamander on immune function of mice

作　　者：曲敏[1] 闫欣[2] 李伟[2,3] 佟长青[4,2] 孔亮[5] 金桥[2] 谭成玉[5] 冯叙桥[1] 

机构地区：[1]沈阳农业大学食品学院,辽宁沈阳110161 [2]大连海洋大学食品科学与工程学院,辽宁大连116023 [3]张家界(中国)金驰大鲵生物科技有限公司,湖南张家界427400 [4]东北林业大学盐碱地生物资源环境研究中心,东北油田盐碱植被恢复与重建教育部重点实验室,黑龙江哈尔滨150040 [5]大连海洋大学海洋环境工程学院,辽宁大连116023

出　　处：《北京农学院学报》2012年第1期42-44,共3页Journal of Beijing University of Agriculture

基　　金：国家自然科学基金(31071612);国家自然科学基金(21075012);湖南省科学计划厅科技计划项目(2010FJ6096);张家界市科技局科技计划项目(2010ZD019)

摘　　要：按体质量将清洁级昆明种小鼠分成对照组(0g/kg.bw)以及低(0.01g/kg.bw)中(0.05g/kg.bw)高(0.1g/kg.bw)3个剂量组,分别以不同剂量的大鲵低聚糖肽饲喂小鼠8d后,测定小鼠血清中IgG含量、吞噬鸡红细胞的巨噬细胞数以及T淋巴细胞活性。结果显示,与对照组相比,低、中、高各剂量组小鼠血清中IgG含量、吞噬鸡红细胞的巨噬细胞数以及T淋巴细胞活性均显著提高。表明大鲵低聚糖肽可以有效提高小鼠的免疫功能。The effect of glycopeptides of giant salamander （Andrias davidianus） on the immunity of mice was studied. The mice were divided into the groups of control （0 g/kg·bw）, low-dose（0.01 g/kg·bw）, medium-dose（0.05g/kg·bw）and high dose （0.1 g/kg·bw）, and were fed with glycopeptides at different levels for 8 d. The amounts of antibody in mice blood, the phago- cytic capacity of maerophages and the amounts of positive ANAE cell were analyzed. The results showed that the glycopeptides at three levels obviously improved the amounts of antibody, enhanced the phagocytic capacity of macrophages and increased the amounts of positive ANAE cell compared with the control. Therefore, the immunological function of mice was improved by the glycopeptides of giant salamander.

关 键 词：大鲵低聚糖肽 小鼠 免疫功能 

分 类 号：Q331[生物学—遗传学] Q959.53