Establishing a cancer cell in the inflammatory tissue： an epigenetic circuit  

作　　者：Wenjing Mu Lijian Hui 

机构地区：[1]State Key Laboratory of Cell Biology,Shanghai Institute of Biochemistry and Cell Biology,Shanghai Institute for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China

出　　处：《Acta Biochimica et Biophysica Sinica》2012年第4期279-280,共2页生物化学与生物物理学报（英文版）

基　　金：We would like to thank Latifa Bakiri, Xianghuo He, and Zhixin Qiu for critical reading of the manuscript. Work in Lijian Hui laboratory is partly funded by National Basic Research Program of China （2012CB945001）, National Natural Science Foundation of China （31071238）, and Chinese Academy of Sciences （the Hundred Talents Program）.

摘　　要：Hepatocellular carcinoma （HCC） is a leading cause of cancer death worldwide. Risk factors, such as viral infec- tion, aflatoxin intake, and alcohol abuse, induce frequent hepatic cell death and chronic liver pathologies. It has now been well accepted that dead hepatocytes trigger a local in- flammatory response, including increased inflammatory cytokines secretion and immune cell infiltration. Repeated cell death and compensatory proliferation in a background of chronic inflammation is believed to lead to the trans- formation of surviving cells that may carry genetic muta- tions; therefore, ultimately enhancing tumor initiation and promotion .Hepatocellular carcinoma （HCC） is a leading cause of cancer death worldwide. Risk factors, such as viral infec- tion, aflatoxin intake, and alcohol abuse, induce frequent hepatic cell death and chronic liver pathologies. It has now been well accepted that dead hepatocytes trigger a local in- flammatory response, including increased inflammatory cytokines secretion and immune cell infiltration. Repeated cell death and compensatory proliferation in a background of chronic inflammation is believed to lead to the trans- formation of surviving cells that may carry genetic muta- tions; therefore, ultimately enhancing tumor initiation and promotion .

分 类 号：Q555.7[生物学—生物化学] Q279