钙信号调节异常在房颤电重构过程中的作用  

Role of calcium management abnormalities during electrical remodeling in progression of atrial fibrillation

作　　者：钱海超[1] 张鹤萍[1] 吴永全[1] 严松彪[1] 

机构地区：[1]首都医科大学附属北京友谊医院心内科,北京100050

出　　处：《心脏杂志》2012年第2期267-270,共4页Chinese Heart Journal

摘　　要：心房颤动(AF)是一种多因素导致的疾病,持续性AF后期不可避免要有结构上出现相应的改变,故在早期电重构期进行针对性的治疗很有必要。本文主要从AF电重构产生的生理基础、AF患者钙信号的改变及AF药物治疗的新思想方面做一综述。Atrial fibrillation （AF） is a multifactorial disease and the mechanisms that underlie AF are various. Long-term persistence of AF unavoidably causes structural remodeling changes; therefore, it is crucial to treat early electrical atrial remodeling as a target in anti-AF therapy. Here we reviewed the physiological bases of electrical atrial remodeling, the unique features of atrial intraeellular Ca2＋ management in AF patients and the novel medical treatments for AF.

关 键 词：心房颤动 钙超载 钙泄漏 

分 类 号：R541.75[医药卫生—心血管疾病]