十种抗生素在马体内的代谢动力学  

PHARMACOKINETICS OF TEN ANTIBIOTICS IN HORSES

作　　者：李涛[1] 解启英 佟恒敏[1] 王振隆 乔桂林[1] 

机构地区：[1]东北农学院兽医系

出　　处：《中国农业科学》1990年第3期76-79,共4页Scientia Agricultura Sinica

摘　　要：本文报告了十种抗生素在健康成年马体内的代谢动力学过程。十种抗生素为噻孢霉素、红霉素、氨苄青霉素、苯唑青霉素、四环素、氯霉素、洁霉素、链霉素、庆大霉素与卡那霉素,它们的主要动力学参数如下: 消除半衰期(t_(1/2)β)分别为0.5、2.91、2、23、2.36、5、79、1.77、8.08、3.05、2.18与2.30(h);总清除率(Cl_B)分别为0.3877、1.5512、0.3946、1.0190、0.0785、1.0760、0.1803、0.0872、0.1233与0.0868(ml/kg·h);曲线下面积(AUC)分別为49.12、10.52、28.50、15.08、159.43、31.97、98.48、258.27、19.11与116.14、(μg·h/ml).还计算了噻孢霉素、洁霉素、红霉素、庆大霉素、链霉素、卡那霉素、氨苄青霉素与四环素的多剂量给药参数。Pharmacokinetic process of ten antibiotics viz.cephalothin, erythromycin, ampicillin, oxacillin, tetracycline, chloramphenicol, lincomycin, streptomycin, gentamicin and kanamycin were determined in biological samples of healthy adult horses.Pharmacokinetic parameters of the ten antibiotics are as follows:The elimination half-life(t_(1/2β)was 0.5,2.91,2.23,2.36,5.79, 1.77, 8.08, 3.05, 2.18, and 2.30 (h), respectively; the total body clearance (CI_B) was 0.3877, 1.5512, 0.3946, 1.0190, 0.0785, 1.0760, 0.1803,0.0872, 0.1233 and 0.0868 (ml/kg.h), respectively; the area under curve (AUC) was 49.12, 10.52, 28.50, 15.08, 159.43, 31.97, 98.48, 258.27, 19.11 and 116.14 (μg.hr/ ml), respectively.Parameters of multiple dosing of cephalothin, lincomycin, erythromycin, gentamycin, streptomycin, kanamycin,ampicillin and tetracycline were calculated as follows: r was 4, 12, 6, 8, 11, 8,6, 6 (h), respectively; R was 1, 1.56, 1.23, 1.16, 1.12, 1.12, 1.09, 1.581, 1.15, respectively; C was 12.28, 8.20, 1.75, 2.39, 18.02, 15.96, 4.75, 11.34, (μg/ml), respectively; (Css) max 223.99, 9.66, 10.34, 6.19, 31.82, 28.06, 8.89, 74.99 (μg/ml), respectively; (Css) rain was 0.06, 6.23, 0.47, 0.43, 5.35, 4.56, 2.17, 2.77 (μg/ml), respectively.

关 键 词：抗生素 马 药代动力学 

分 类 号：S821.1[农业科学—畜牧学]