针刺对肥胖大鼠下丘脑腹内侧核作用的研究  

Action of Acupuncture on Ventromedial Neucleus of Hypothalamus in the Rat of Obesity

作　　者：刘志诚[1] 孙凤岷 苏静 赵玫[1] 朱苗花[1] 王沂争 魏群利[1] 李嘉[1] 顾云[1] 

机构地区：[1]南京中医药大学第二临床医学院,南京市汉中路282号210029 [2]南京人口管理干部学院

出　　处：《中医杂志》2000年第1期25-26,共2页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(39270838)

摘　　要：观察针刺对肥胖大鼠下丘脑腹内侧核(VMH)神经细胞自发放电和单胺类神经递质水平的影响。结果显示,肥胖组较正常组VMH中酪氨酸(Tyr)、多巴胺(DA)水平均低下,5-羟色胺(5—HT)和5-羟吲哚乙酸(5—HIAA)水平升高;VMH神经细胞自发放电频率显著低下。针刺在取得减肥效果的同时,可以显著提高VMH神经细胞自发放电频率;还可以升高VMH组织中Tyr、DA、色氨酸(Trp)、5—HT/5—HIAA水平,回降5—HT水平。提示什刺对VMH的良性调整作用可能是针刺减肥关键性因素之一。Effects of acupuncture on spontaneous discharges of nerve cells in ventromedial neucleus of hypothalamus (VNH) and levels of monoamine neurotransmitters in rats of obesity were observed. Results indicated that levels of tyrosine (Tyr) and dopamine f DA) were decreased, and the levels of 5 -hydroxytryptamine (5 - HT) and 5 - hydroxyindole acetic acid (5 - HIAA) increased in VNH; The frequency of spontaneous discharges of nerve cells in VNH lowered significantly in the obesity group as compared with those in the normal group; When acupuncture attained effect of weight reduction, the frequency of spontaneous discharges of nerve cells in the VMH increased obviously; the levels of Tyr, DA, tryptamine , and 5 - HT/5 - HIAA increased, and 5 - HT level decreased in VMH tissue. It is suggested that the benign regulative action of acupuncture on VNH is possibly one of the crucial factors for acupuncture in reducing body weight.

关 键 词：下丘脑 肥胖症 针灸疗法 腹内侧核 大鼠 

分 类 号：R245[医药卫生—针灸推拿学]