耳-体穴电针对家兔胆道功能的调节及迷走神经的作用  

Regulatory effect of electroacupuncture at auriculo-body acupoints on the functions of the biliary system and actions of the vagus nerve

作　　者：朱元根[1] 贲卉[1] 叶燕燕[1] 徐青燕[1] 

机构地区：[1]中国中医科学院针灸研究所,北京市100700

出　　处：《世界华人消化杂志》2012年第7期552-557,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.39270833;科研院所技术开发研究专项基金资助项目;No.2011EG152313~~

摘　　要：目的:探讨耳-体穴电针对胆道系统疾病的治疗及迷走神经在调节胆道系统功能中的作用.方法:建立家兔实验性胆总管结石症的模型;以家兔胆汁流量、胆道压力及奥狄氏括约肌(oddi)肌电为指标,观察迷走神经对胆道系统功能的影响;以20Hz频率电针耳穴"胰胆区"及体穴"胆俞"30min,观察各项指标的变化.结果:结石症家兔因结石的存在,诱发了胆汁流量、胆道压力、oddi括约肌放电病理性增加,oddi括约肌肌电从有规律发放转变为无序的爆发性发放(胆汁流量、胆道各部位压力分别为15.50±5.10vs11.35±4.06,41.26±2.31vs16.70±2.33,41.30±2.56vs16.70±2.43,52.80±3.10vs29.33±3.73,均P<0.01);耳-体穴电针的调节作用促使胆石症模型家兔的胆汁流量进一步增加,以利结石排出(针后立即及针后30min依次为17.25±7.29,18.16±5.05vs15.66±5.66,P<0.05,P<0.01),针后30min胆道上端压力稍有增加(43.58±1.77vs42.00±1.70,P<0.01),但胆总管压力和oddi括约肌张力皆降低(前者40.03±0.77vs41.25±1.72,P<0.05;后者48.25±2.91vs53.50±3.20,P<0.01),并恢复节律性放电;耳-体穴电针对去除迷走神经的胆石症家兔胆道功能的即时调整作用不明显,但停电针30min后可见胆汁流量增加,胆总管压力和oddi括约肌张力降低(均P<0.05).结论:迷走神经对维持家兔的正常胆道系统功能是必须的;耳-体穴电针主要通过迷走神经对胆道功能失常动物发挥及时的、快速的调整作用,可能有体液途径对胆道系统功能发挥缓慢的、持久的调整作用.AIM： To study the mechanism of electroacupuncture at auriculo-body acupoints in treating disorders of the biliary system and the actions of the vagus nerve in regulating biliary functions. METHODS： A rabbit model of common bile duct stones was created. The influence of the vagus nerve on the functions of the biliary system was evaluated using bile current capacity, biliary duct pressure, and Oddi sphincter myoelectricity. The changes in these parameters were observed after electroacupuncture at a frequency of 20 Hz for 30 minutes at ＂Yi-Dan＂ area, Auriculoacupoint and ＂Danshu＂. RESULTS： A pathological increase in bile current capacity, biliary duct pressure, and Oddi sphincter myoelectricity was observed in rabbits with common bile duct stones. Oddi sphincter myoelectricity was transformed from orderly electric discharge into disorder and paroxysmal discharge. Electroacupuncture at ear-body acupoints further increased bile current capacity. The myotensity of the Oddi sphincter was decreased and myoelectricity was restored into rhythmicity. The regulatory effect of electroacupuncture at ear-body acupoints on biliary duct functions was not obvious in rabbits whose vagus nerve was removed. Increased bile current capacity and reduced biliary duct pressure were observed 30 minutes after stopping electroacupuncture. CONCLUSION： The integrity of the vagus nerve is necessary for maintaining the normal functions of the biliary system in rabbits. Electroacupuncture at ear-body acupoints regulates biliary duct function mainly through modulating the vagus nerve.

关 键 词：耳-体穴电针 胆道系统功能 胆总管 迷走神经 

分 类 号：R245[医药卫生—针灸推拿学]