回直肠吻合分流术对泻剂依赖型慢传输便秘大鼠的排便影响  

Colonic bypass with ileorectal anastomosis improves defecation in rats with laxative-dependent slow transit constipation

作　　者：张卫平[1] 江滨[2] 吴银亚[1] 丁曙晴[2] 霍明东[1] 徐速[1] 皇甫少华[1] 

机构地区：[1]南京中医药大学,江苏省南京市210000 [2]南京市中医院全国中医肛肠医疗中心,江苏省南京市210000

出　　处：《世界华人消化杂志》2012年第6期509-513,共5页World Chinese Journal of Digestology

基　　金：南京市卫生局重点基金资助项目;No.ZKX11004;南京市科学技术委员会基金资助项目;No.201108004;江苏省中医药局基金资助项目;No.LZ11105~~

摘　　要：目的:建立泻剂依赖型大鼠慢传输型便秘(STC)模型,完成回肠直肠吻合分流手术,观察该术式对STC大鼠排便的影响,初步探讨其对STC的治疗效果.方法:72只SD大鼠,随机取10只作为正常对照组,其余62只用大黄小剂量递增灌胃造模.造模过程中死亡5只,剩余57只,手术前处死12只作为模型对照组.剩余的45只大鼠,随机35只手术组,10只自然恢复组,测定并比较各组大鼠间胃肠传输时间及粪便干湿质量比.结果:(1)胃肠传输时间(min):正常对照组为341.77±31.89,模型组为398.83±25.17,1 mo恢复组为428.73±36.19,术后1 mo组为183.6±35.96,各组间对比有明显差异(P<0.05);(2)粪便干湿质量(干/湿):正常对照组为0.444±0.048,模型组为0.495±0.053,1 mo恢复组为0.531±0.033,术后10 d测量为0.139±0.061,术后1 mo为0.372±0.058,各组间对比差异显著(P<0.05).结论:回直肠吻合分流术对STC大鼠的胃肠传输时间及粪便性状影响显著,明显改善了便秘大鼠的症状,且术后1 mo较术后10 d腹泻症状明显改观.AIM：To develop a rat model of laxative-dependent slow transit constipation（STC） and to observe the impact of colonic bypass with ileorectal anastomosis on defecation in model rats.METHODS：A total of 72 rats were used in the study,of which 10 were included in normal control group,and 62 were used to induce STC by intragastric administration of gradually increasing doses of rhubarb suspension.STC was successfully induced in 57 rats,and 12 of them were used as model controls and killed before operation.The remaining 45 STC rats were randomized into operation group（n = 35） and recovery group（n = 10）.Gastrointestinal transit time（GTT）,dry weight,wet weight and ratio of dry weight to wet weight of the feces were determined.RESULTS：Gastrointestinal transit time（min） was 341.77 ± 31.89 in the normal control group,398.83 ± 25.17 in the model group,428.73 ± 36.19 in the recovery group,and 183.6 ± 35.96（1 mo） in the operation group,with a significant difference among different groups（P 0.05）.The ratio of dry weight to wet weight of the feces was 0.444 ± 0.048 in the normal control group,0.495 ± 0.053 in the model group,0.531 ± 0.033 in the recovery group,0.139 ± 0.061（10 d） and 0.372 ± 0.058（1 mo） in the operation group,with a significant difference among different groups（P 0.05）.CONCLUSION：Colonic bypass with ileorectal anastomosis improves defecation in rats with STC.

关 键 词：泻剂依赖型慢传输型便秘 回直肠吻合分流术 外科治疗 

分 类 号：R656.7[医药卫生—外科学]