猪胰岛细胞异种移植治疗糖尿病的研究进展  

Advances in research of pig islet xenotransplantation for diabetes

作　　者：朱海涛[1] 于良[1] 王博[1] 

机构地区：[1]西安交通大学医学院第一附属医院肝胆外科,陕西省西安市710061

出　　处：《世界华人消化杂志》2012年第9期737-742,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.30700772~~

摘　　要：猪胰岛细胞移植是一种极具潜力治疗糖尿病的方法.目前仍以实验室研究为主,其临床应用主要面临两大挑战:高质量的活性胰岛短缺与异种免疫排斥反应.近年来随着胰岛分离纯化技术的改进、新型免疫耐受诱导策略的出现及移植技术的发展等,猪胰岛细胞异种移植取得了巨大的进展并进入临床前期研究.本文就猪胰岛移植物的制备、排斥反应与防治措施、移植安全性及临床研究等方面的进展作一综述.Pig islet xenotransplantation is effective in treating diabetes.Nowadays,the research of islet xenotransplantation is still in the research phase,and its clinical use is mainly restricted by the shortage of functional islets and graft rejection.In recent years,several studies have demonstrated the feasibility of successful preclinical pig islet xenotransplantation.Moreover,promising results concerning prolonged insulin independence were achieved with the improvement of islet isolation technologies,application of novel immunotherapeutic strategies,and the development of transplantation surgery.This review aims to elucidate the advances in the separation and preparation of transplanted pig islet,immunological rejection and treatments,potential safety problems,and clinical studies.

关 键 词：猪胰岛细胞 异种移植 糖尿病 免疫排斥 

分 类 号：R587.1[医药卫生—内分泌]