eNOS基因多态性与成人过敏性紫癜的关系  

ASSOCIATION OF ENOS GENE POLYMORPHISM WITH GENETIC SUSCEPTIBILITY TO HENOCH-SCHONLEIN PURPURA

作　　者：安锦丹[1] 于晶[2] 梅松柳[2] 王洪伟[1] 展涛[1] 杨国荣[2] 郭素芬[1] 曹永[1] 颜彬[1] 

机构地区：[1]牡丹江医学院病理教研室,黑龙江牡丹江157011 [2]牡丹江医学院附属红旗医院肾内科,黑龙江牡丹江157011

出　　处：《牡丹江医学院学报》2012年第1期1-3,共3页Journal of Mudanjiang Medical University

基　　金：黑龙江省卫生厅科研项目(2011-322);牡丹江市科学技术计划项目(Z2011s003)

摘　　要：目的:探讨内皮型一氧化氮合酶基因G894T多态性与过敏性紫癜和过敏性紫癜性肾炎易感性的关系。方法:应用PCR-RFLP技术检测90例过敏性紫癜/过敏性紫癜性肾炎患者与98例正常对照组内皮型一氧化氮合酶基因G894T多态性。结果:eNOS基因型构成比在HSP组与正常对照组、HSPN组与正常对照组之间差异有显著性(P=0.022,P=0.025),但在HSP和HSPN之间差异无显著性(P=0.585)。eNOS-GG基因型和G等位基因具有较高的患HSP和HSPN的危险性。结论:携带eNOS基因G894T多态性增加患HSP/HSPN的危险。Objective：To explore the relationship between G894T gene polymorphism of Endothelial nitric oxide synthase （eNOS） gene and Henoch - Schonlein purpura （HSP）. Methods： G894T polymorphism of eNOS gene was analyzed in 90 atients with HSP/ HSPN and 98 healthy adults served as control by using PCR - RFLP. Results： The eNOS genotype distribution was significantly different between HSP and normal control, and between HSPN and normal control（ P = 0.022,P =0.025）, but no difference was observed be- tween HSP and HSPN（P =0.585）. The eNOS gene GG genotype and G allele has has a high risk for HSP and HSPN. Conclusion： eNOS gene G894T polymorphism is associated with HSP/HSPN.

关 键 词：过敏性紫癜 过敏性紫癜性肾炎 内皮型一氧化氮合酶 基因多态性 

分 类 号：R725.5[医药卫生—儿科]