尼可地尔-乙基纤维素固体分散物的药物释放动力学的研究  

Studies on the release kinetics of nicrandil-ethylcellulose solid dispersions

作　　者：王晋[1] 陈鹏[1] 黄群[2] 邹晓颖[1] 张汝华[3] 

机构地区：[1]北京放射医学研究所,北京100850 [2]福建中医学院中药制剂教研室,福州350003 [3]沈阳药科大学药剂教研室,沈阳110015

出　　处：《中国药学杂志》2000年第1期30-32,共3页Chinese Pharmaceutical Journal

摘　　要：目的 :研究乙基纤维素固体分散物颗粒及片剂的释放动力学及释放机制。方法 :测定尼可地尔 乙基纤维素固体分散物颗粒及片剂的释放曲线 ,并用 3种模型方程———零级动力学方程、一级动力学方程、Higuchi模型方程进行线性拟合 ,根据所得方程的相关系数的大小顺序 ,确定颗粒及片剂的释放动力学及释放机制。结果 :颗粒释放动力学拟合顺序为 :零级动力学模型、Higuchi模型、一级动力学模型 ;片剂释放动力学拟合结果的优劣顺序为 :Higuchi模型、一级动力学模型、零级动力学模型。结论 :颗粒释放遵从零级动力学模型方程 ,为表面扩散机制 ;片剂释放遵从Higuchi方程 ,为骨架扩散机制。OBJECTIVE: To study the release kinetics and release mechanisms of ethylcellulose solid dispersion granules and tablets METHODS: The dissolution curves of nicrandil ethylcellulose solid dispersion granules and tablets were measured The release data were fitted with three model equations The release kinetics and release mechanisms of granules and tablets were judged by the sequence of correlation coefficients of three fitting equatuions RESULTS: The sequence of fitness (from good to bad) of granules dissolution model was: zero order model, Higuchi model, first order model The sequence of fitness (from good to bad) of tablets disslution model was: Higuchi model, first order model, zero order model CONCLUSION: The drug release of granules was surface diffusion mechanism, following zero order release kinetics The drug release of tablets was matrix diffusion mechanism, following Highchi square root equation

关 键 词：乙基纤维素 固体分散物 释放动力学 尼可地尔 

分 类 号：R944.9[医药卫生—药剂学]