马来酸三甲氧苯丁氨酯镇痛机制的初步研究  

The Analgesic Mechanism of Trimebutine Maleate

作　　者：马涛[1] 刘玉兰[1] 盛男[1] 

机构地区：[1]沈阳药科大学药学系,沈阳110015

出　　处：《沈阳药科大学学报》2000年第1期58-60,共3页Journal of Shenyang Pharmaceutical University

摘　　要：对马来酸三甲氧苯丁氨酯（ＴＭ） 镇痛作用的机制进行了初步探讨．结果显示，脑室内注射ＴＭ４０ 、８０ μｇ／ 鼠能够显著抑制小鼠扭体反应，表明ＴＭ 的镇痛作用有中枢参与．利血平、纳洛酮能够减弱ＴＭ 的镇痛作用，ＣａＣｌ２ 和ＥＤＴＡ 则分别减弱和增强其镇痛作用．表明ＴＭ 的镇痛作用可能与阿片系统。The analgesic effect of trimebutine maleate (TM) and its mechanism were studied in this paper.It was found that the writhing response induced by acetic acid was inhibited by TM (40、80 μg/mouse,icv).TM induced analgesia was significantly reduced by reserpine and naloxone,and its analgesic effect was reduced and inhanced by CaCl\-2 and EDTA respectively.It was concluded that the analgesic effect of TM was of partical central action and might be related to the opioid receptor,the central monoamine transmitters and the inhibition of calcium influx.

关 键 词：马来酸 三甲氧苯丁氨酯 镇痛 TM 胃功能调节 

分 类 号：R975.1[医药卫生—药品]