左旋咪唑对鸡传染性法氏囊病疫苗接种鸡的免疫调节作用的研究  

STUDY ON THE FUNCTION OF IMMUNE REGULATION OF LEVAMISOLE TO CHICKEN INOCULATED BY IBD VACCINE

作　　者：王世礼[1] 王晓亮 武占银 王进香 许立华 

机构地区：[1]宁夏农学院,宁夏永宁750105 [2]宁夏回族自治区兽医工作站,银川750001

出　　处：《宁夏农学院学报》2000年第1期7-9,共3页Journal of Ningxia Agricultural College

基　　金：宁夏教委资助项目

摘　　要：本研究采用 70只无母源抗体的 14日龄雏鸡 ,随机分为试验组和对照组。两组雏鸡均口服接种IBD疫苗 1只份。从疫苗接种的当日开始 ,在试验组雏鸡的饲料内按每天每公斤体重 15mg计算 ,拌入盐酸左旋咪唑 ,连服三日 ;对照组不服左旋咪唑。于接苗后的 10、2 0、30、40和 5 0天 ,从两组雏鸡中随机各取 30只由翅静脉采血 ,析出血清 ,供测定血清抗体用。同时 ,从各组鸡血样中随机各取 10份 ,作成血涂片 ,供检查T淋巴细胞用。试验结果 :试验组琼脂扩散抗体出现的时间似比对照组稍早、抗体阳性率下降略迟 ,但两组间差幅不大。试验组T淋巴细胞明显高于对照组。由此可见 ,雏鸡在接种IBD疫苗的同时 ,服用左旋咪唑 ,可以促进T淋巴细胞增殖 。In this research,70 chickens(after inoculation 14 days,nonmenternal antibody)were divided into two groups(treating group and check group). All of these chickens were inoculated by IBD vaccine at routine dosage. The chickens in treated group fed feed mixed levamisole hydrochloride 15mg/kg/day from first day to third day after inocuulation for 3 days. The chickens in check group fed no levamisole in feed. After inoculating the vaccine 10, 20, 30, 40 and 50 days, the 30 chickens form each group to collect blood respectively, to segregate serum that used for testing serum antibody. In the same time, the blood samples from each group chickens take 10 samples to do blood smear to be used for testing T lumphocyte. The experimental results show; that the agar difusion antibody of treated group appears earlier and the rate of postitve decreases later than of check group, but the difference between two of them is no significant. The T lymphocyte in chickens of treated group is more than of check group clearly. Therefore, chicken inoculated IBD vaccine and fed levamisole can promote hyperplasia of T lymphocyte, strengthen immunity of it.

关 键 词：左旋咪唑 鸡 IBD 疫苗接种鸡 免疫调节作用 

分 类 号：S858.312.4[农业科学—临床兽医学] S859.795[农业科学—兽医学]