可吸收材料生物蛋白胶及明胶海绵在肝部分切除的应用  

Applications of absorbable fibrin glue and gelatin sponge in partial liver resection

作　　者：何艳新[1] 刘超[1] 

机构地区：[1]郑州大学第二附属医院普外科,河南省郑州市450014

出　　处：《中国组织工程研究》2012年第12期2180-2182,共3页Chinese Journal of Tissue Engineering Research

摘　　要：背景:生物蛋白胶广泛应用于各种外科手术中对富含小血管创面渗血的处理。目的:通过在肝部分切除中应用组织可吸收性医用生物蛋白胶,分析其对手术时间及肝部分切除后止血效果的影响。方法:对42例肝部分切除患者随机等分为实验组和对照组。实验组在肝部分切除后,缺损处喷洒医用生物蛋白胶封闭,并以明胶海绵剪成多块小片段混合医用生物蛋白胶以覆盖断面来代替常规缝合断面。对照组仅缝合收拢肝组织缺损。结果与结论:实验组使用的生物蛋白胶可迅速附着于创面,实验组患者肝部分切除的手术时间、出血量、引流量及渗血持续时间均明显小于对照组(P<0.05),且2组患者的住院天数和住院费用的差异无显著性意义(P>0.05)。提示在肝部分切除中应用医用生物蛋白胶可以在不增加患者费用及住院时间的同时,有效降低手术时间、减少肝部分切除后出血。BACKGROUND：Fibrin glue is widely applied for blood oozing wounds in various surgeries.OBJECTIVE：To apply absorbable fibrin glue and gelatin sponge in partial liver resection so as to analyse the operation time and postoperative hemostasis effect.METHODS：Totally 42 patients undergoing partial liver resection were randomly divided into two groups：in the control group defects of liver tissue were folded after partial hepatectomy and hemostasis;in the experimental group,the wound was sprayed with fibrin glue to achieve hemostasis effect and the defect was filled with fibrin glue and gelatin sponge cutting into pieces to replace the conventional suture.RESULTS AND CONCLUSION：Operation time,bleeding volume,drainage volume and duration of blood oozing in the experimental group were significantly lower than those in the control group（P 0.05）,while length of hospital stay and hospital costs had no difference between the two groups（P 0.05）.Combined application of fibrin glue and gelatin sponge in partial liver resection can effectively reduce the operation time and reduce postoperative hemorrhage without increasing patient＇s cost and hospital stay.

关 键 词：生物蛋白胶 可吸收性材料 明胶海绵 肝部分切除 生物材料 

分 类 号：R318[医药卫生—生物医学工程]