VX2肿瘤种植于肾静脉上下建立的兔下腔静脉模型  

Establishment of an inferior vene cava animal model by VX2 tumor implanted into the suprarenal and infrarenal vein in rabbits

作　　者：张元国[1] 任为[1] 

机构地区：[1]重庆医科大学附属第一医院血管外科,重庆市400016

出　　处：《中国组织工程研究》2012年第11期1999-2002,共4页Chinese Journal of Tissue Engineering Research

基　　金：重庆市卫生局医学科研项目面上项目(2010-2-041)~~

摘　　要：背景:目前,临床上对恶性肿瘤侵犯肾静脉以上、以下的下腔静脉处理原则及方式还有争议,而类似的动物模型尚少见文献报道。目的:分别建立VX2肿瘤侵犯肾静脉以上、以下的下腔静脉的动物模型,观察并对比分析其生长,以及对下腔静脉和腹主动脉的影响。方法:将24只实验兔随机摸球法均分为肾静脉以上组和肾静脉以下组,分别将VX2肿瘤组织块种植在兔肾静脉以上、以下的下腔静脉附近软组织内,每周在超声下观察肿瘤的大小,下腔静脉和腹主动脉管径大小,对周围组织的侵犯情况。结果与结论:所有肿瘤均种植成功。两组肿瘤大小与生长时间均呈显著正相关(r1=0.894,r2=0.879),下腔静脉管径及腹主动脉管径与肿瘤大小均显著负相关(r3=-0.663,r4=-0.834;r5=-0.826,r6=-0.870)。两组肿瘤大小变化差异无显著性意义(P=0.293>0.05)。在观察期末,肾静脉以上组下腔静脉管狭窄不到50%,肾静脉以下组下腔静脉管已完全闭塞,且有效避免了对腹主动脉的压迫(狭窄不到50%),结果说明VX2肿瘤种植于肾静脉以下可以得到较理想的动物模型。BACKGROUND： At present, the principle and procedure for the treatment of tumor invading suprarenal and infrarenal inferior vene cave （IVC） are in dispute, but corresponding animal model is rarely reported in the literatures. OBJECTIVE： To establish the experimental animal model of the VX2 tumor invading suprarenal and infrarenal IVC, and to observe the influence on tumor growth and the IVC and abdominal aorta （AA）. METHODS： Twenty-four rabbits were randomly divided into suprarenal group and infrarenal group, the prepared VX2 tumor tissue mass was transplanted into the soft tissues around the suprarenal and infrarenal IVC. Tumor size, diameter of the IVC and the AA, and the surrounding tissues were detected by ultrasound once a week as long as 5 weeks after implanted. RESULTS AND CONCLUSION： All VX2 tumors had been growing successfully in the experimental rabbits. Tumor size was significantly positive related to the growth time in two groups （r1=0.894, r2=0.879）; the diameter of the IVC and AA were significantly negative related to tumor size in two groups （r3=-0.663, r4=-0.834; r5=-0.826, r6=-0.870）. The difference of tumor size was not significant between two groups （P1=0.2930.05）. In the observation period, the stenosis of IVC was less than 50% in suprarenal group; the IVC in infrarenal group was completely blocked and effectively avoided the pressure on the AA. VX2 tumor tissue mass transplanted into the soft tissues around the infrarenal IVC leads to an ideal animal model.

关 键 词：下腔静脉 VX2 瘤 兔 肿瘤大小 动物模型 

分 类 号：R318[医药卫生—生物医学工程]