创面修复“TIME”原则及其意义  

"TIME" principles and its clinical significance in wound repair

作　　者：徐媛[1] 刘宏伟[1] 

机构地区：[1]暨南大学附属第一医院整形外科,再生医学教育部重点实验室,广东省广州市510630

出　　处：《中国组织工程研究》2012年第11期2059-2062,共4页Chinese Journal of Tissue Engineering Research

基　　金：国家重点基础研究发展规划资助项目(2005CB522603);国家自然科学基金资助项目(30772257,30973127);中央高校基本科研业务费专项资金资助项目(21611416)等资助~~

摘　　要：背景:随着人们对创面愈合机制研究的深入和创面处理经验的积累,创床的准备对于创面修复的重要性越来越引起人们的高度重视。目的:全面了解创面愈合的机制,明确影响创面愈合的各种影响因素及其作用。方法:电子检索中国期刊全文数据库(1994/2011)和PubMed数据库(1994/2011),检索词分别为"TIME原则,创面准备,创面愈合"和"TIME principles,wound bed preparation,wound healing",语言分别设定为中文和英文,分析创面愈合临床应用原则及效果的研究进展。结果与结论:共检索到文献498篇,阅读标题和摘要后,按纳入标准,共纳入22篇。TIME为创面处理过程中创床准备4项原则性的方法的首个英文字母的缩写,即:T指清除创面坏死组织(tissue);I指控制炎症、减轻感染(infection/inflammation);M指保持创面正常的湿度为肉芽组织生长和创面上皮化创造条件(moisture);E指去除创缘迁移受损的表皮(edge of wound,non migrating)。目前TIME原则作为一个有价值的创面处理指导工具受到临床医生的好评,并应用于临床实践。BACKGROUND： While the cellular and molecular mechanisms of wound healing have been understood gradually and the experiences of wound bed management have been accumulated, the importance of wound bed preparation to wound repair has recently attracted more attention. OBJECTIVE： To fully analyze the mechanisms of wound healing, various influence factors and their effects in this progress. METHODS： An on line search of CNKI and PubMed databases was performed for articles published between 1994 and 2011, using key words of ＂TIME principles, wound bed preparation, wound healing＂ in Chinese and English, respectively. The clinical application principles and outcomes of wound healing were analyzed. RESULTS AND CONCLUSION： A total of 498 papers were collected, and 24 of them were included according to inclusive criteria. TIME is the initials of four principles in wound bed management. T means to remove the necrotic tissue. I means to control the infection and to reduce the inflammation. M means to keep the wound moisture under normal condition for the granulation tissue growth and re-epithelialization. E means to remove non migrating epidermis at the edge of wound. As a valuable guidance tool for wound management, the TIME concept has been applied to clinical practice, and has been widely appreciated by clinicans.

关 键 词：创伤愈合 溃疡 清创 慢性创面 创面分析 

分 类 号：R318[医药卫生—生物医学工程]