植入式人工肛门括约肌系统的实现及动物实验  

Implementation and animal experiment of an implantable artificial anal sphincter system

作　　者：许茜茜[1] 刘华[1] 颜国正[1] 

机构地区：[1]上海交通大学电子信息与电气工程学院820研究所,上海市200240

出　　处：《中国组织工程研究》2012年第13期2336-2341,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(30800235);教育部博士点基金新教师基金项目(20070248094);上海交通大学"医工(理)交叉研究项目(YG2009ZD103)~~

摘　　要：背景:研制新型的符合人体生理需求的人工肛门括约肌系统具有十分重要的意义。目的:设计一种新型植入式人工肛门括约肌系统。方法:利用无线通讯模块和压力传感器重建排便控制机制,并由经皮能量传输模块供电,采用机电系统模拟人体自然器官的功能,最终实现人体肛门括约肌的控制效果。结果与结论:设计并实现了一种新型的植入式人工肛门括约肌系统,在重建排便机制和模型的基础上,一定程度上恢复肛门失禁患者的生物反馈控制能力,并带有经皮能量传输模块,为体内系统长期无缆式供电提供可能。该系统实现了植入式动物实验,完成了系统植入可行性和基本功能验证。BACKGROUND：It is important to develop a new kind of implantable artificial anal sphincter system to meet the physiological needs of the human body.OBJECTIVE：To design a new kind of implantable artificial anal sphincter system.METHODS：Wireless communication model and pressure sensors were used to rebuild the mechanism of defection,and the power was supplied with transcutaneous energy transmission model.The electro-mechanical system was adopted to simulate the human natural organ to achieve the control efforts of human anal sphincter finally.RESULTS AND CONCLUSION：A new kind of implantable artificial anal sphincter system was designed and accomplished.The bio-feedback control ability of anus incontinent patients could be recovered in some degree based on the reconstruction of defecation mechanism and model.The implantable artificial anal sphincter system had the module of transcutaneous energy transmission that could provide long-time wireless power for the internal system.The animal experiment was accomplished to verify the feasibility to implant the implantable artificial anal sphincter system and its basic function.

关 键 词：人工肛门括约肌 生物反馈控制 经皮能量传输 植入式动物实验 数字化医学 

分 类 号：R318[医药卫生—生物医学工程]