脂蛋白相关磷脂酶A2与2型糖尿病大血管病变相关性研究  

Correlation between Level of Lipoprotein Associated Phospholipase A2 and Macrovascular Complications in Type 2 Diabetes Mellitus

作　　者：商丽娜[1] 李华[1] 杨再刚[1] 翟倩倩[1] 冯涛[1] 姜丹[1] 田勇 

机构地区：[1]郑州大学第一附属医院老年内分泌科,河南省郑州市450052 [2]郑州市人民医院特需病房

出　　处：《中国全科医学》2012年第12期1326-1328,1331,共4页Chinese General Practice

摘　　要：目的观察2型糖尿病(T2DM)患者血浆脂蛋白相关磷脂酶A2(Lp-PLA2)水平,探讨其与T2DM大血管并发症的关系及临床意义。方法选取69例T2DM患者,其中单纯糖尿病患者31例(单纯糖尿病组)、糖尿病合并大血管病变患者38例(糖尿病并大血管病变组),另选取同期在我院体检的21例健康者为对照组。采用ELISA法检测3组受检者血浆Lp-PLA2水平,并进行比较。结果单纯糖尿病组和糖尿病并大血管病变组患者血浆Lp-PLA2水平显著高于对照组(P<0.05),且糖尿病并大血管病变组Lp-PLA2水平又显著高于单纯糖尿病组(P<0.05)。Lo-gistic回归分析显示:除去混杂因素后,Lp-PLA2水平仍与糖尿病大血管病变直接相关(P<0.05)。结论 Lp-PLA2是糖尿病的独立危险因素之一,对预测糖尿病血管并发症有一定的意义。Objective To explore the correlation between the levels of lipoprotein - associated phospholipase A2 （ Lp - PEA2 ） and macrovascular complications in type 2 diabetes mellitus. Methods 69 patients with T2DM were divided into T2DM without macrovascular complication group （31 cases） and T2DM with maerovascular complication group （38 cases ）. Mean- while, 21 healthy people who received physical examination were selected as control group. ELISA was used to detect the plasma levels of Lp - PLA2 in the three groups. Results The Lp - PEA2 level of T2DM without maerovascular complication group and T2DM with macrovascular complication group was significantly higher than that in control group （P 〈 0. 05 ） , and Lp - PLA2 lev- el of T2DM with maerovaseular group was significantly higher than that of T2DM without maerovaseular group （ P 〈 0. 05 ）. Lo- gistic regression analysis showed that after removing the confounding factors, Lp - PLA2 still directly related to macrovaseular complications of diabetes （ P 〈 0.05 ） . Conclusion Lp - PLA2 level is one of the independent risk factors for diabetes mellitus, and can serve as a biomarker for predicting the early vascular complications in patients with type 2 diabetes mellitus.

关 键 词：糖尿病 2型 脂蛋白相关磷脂酶A2 糖尿病血管病变 

分 类 号：R587.1[医药卫生—内分泌]