伏隔核缺失后海洛因成瘾者线索诱导渴求的fMRI研究  

fMRI study on heroin-related cues induced craving in heroin addicts long after nucleus accumbens ablation

作　　者：常海峰[1] 王亚蓉[1] 李强[1] 王学廉[2] 李玮[1] 朱佳[1] 吴宁[1] 郑颖[1] 李楠[2] 陈磊[2] 王玮[1] 

机构地区：[1]第四军医大学唐都医院放射科,陕西西安710038 [2]第四军医大学唐都医院脑外科,陕西西安710038

出　　处：《实用放射学杂志》2012年第4期491-494,共4页Journal of Practical Radiology

基　　金：国家自然科学基金资助项目（编号：81071142;81071143;30870685）;陕西省科学技术研究发展计划项目（编号：2009K01-65;2010K16-03-02;2010K16-03-01）.

摘　　要：目的 研究伏隔核缺失的海洛因成瘾者在完成药物线索诱导渴求任务时大脑反应,及其与主观渴求程度变化的关系.方法 10例伏隔核缺失的海洛因成瘾者和10例人口学及吸毒史相匹配的海洛因成瘾者纳入该实验.行图片药物线索诱导渴求的fMRI扫描.数据由SPM5软件分析.MR扫描前后,对被试者进行海洛因渴求程度评分.结果 暴露于线索后,海洛因成瘾组渴求明显升高,激活脑区包括海马、尾状核,额下回、颞中回、颞下回、枕中回、顶下小叶;伏隔核缺失组渴求无变化,激活脑区包括海马,颞中回、颞下回、顶下小叶、枕中回;伏隔核缺失组与海洛因成瘾组相比显示伏隔核激活减弱,楔前叶和舌回激活增强.结论 伏隔核在海洛因成瘾者大脑对药物线索诱导渴求的过程中可能起重要作用.Objective To study the relevance between craving and brain response to heroin related cues in heroin addicts long after nucleus accumbens ablation. Methods 10 heroin addicts long after nucleus accumbens ablation and 10 demographically-matched herk oin addicts were included in this study. The subjects underwent the heroin cue induction paradigm of fMRI. The data were analyzed by the SPM5 software. Results The heroin-dependent group reported significantly increased craving following exposure to heroin re lated cues. The activated brain regions included the hippocampus, caudate, inferior frontal gyrus, middle temporal gyrus, gyrus temporalis inferior, middle occipital gyrus and inferior parietal lobule. The group after nucleus accumbens ablation did not report craving change. The activated brain regions included the hippocampus, middle temporal gyrus, gyrus temporalis inferior, inferior parietal lobule and middle occipital gyrus. Compared with the heroin group, the group after nucleus accumbens ablation showed greater activation in nucleus accumbens and lower activation in precuneus and lingual gyrus. Conclusion The nucleus accumbens may play an important role in the process of drug cues-induced craving.

关 键 词：脑 海洛因成瘾 伏隔核 功能磁共振成像 

分 类 号：R338.2[医药卫生—人体生理学] R996[医药卫生—基础医学]