高分辨率MRI评价大脑中动脉狭窄程度与灌注加权成像评估脑供血的研究  

Evaluation of stenosis degree of the middle cerebral artery with high-resolution MRI and brian blood supply with MR perfusion weighted imaging

作　　者：崔恒[1] 程敬亮[1] 张勇[1] 

机构地区：[1]郑州大学第一附属医院磁共振科,河南郑州450052

出　　处：《实用放射学杂志》2012年第4期499-503,共5页Journal of Practical Radiology

摘　　要：目的 探讨高分辨率MRI（high-resolution MRI,HRMRI）判定大脑中动脉（middle cerebral artery,MCA）狭窄程度与脑MRI灌注加权成像（perfusion weighted imaging,PWI）评价脑供血的价值.方法 对30例短暂性脑缺血（TIA）患者行HRMRI以判定单侧MCA狭窄程度,并行MRI PWI检查,得出患侧和镜像侧灌注参数,包括相对脑血容量（relative cerebral blood volume,rCBV）、相对脑血流量（relative cerebral blood flow,rBCF）、相对平均通过时间（relative mean transit time,rMTT）、相对达峰时间（relative time to peak,rTTP）,并对其进行定量分析.结果 30例患者中,HRMRI判定MCA轻度狭窄7例,中度狭窄9例,重度狭窄或闭塞14例;30例灌注均出现异常,rCBF、rMTT、rTTP灌注参数均具有统计学意义,其中MCA中度、重度狭窄或闭塞组狭窄率与rMTT延长百分率之间呈正相关（r=0.897、0.829,P〈0.01）.结论 HRMRI对MCA狭窄程度的评估具有重要价值,联合PWI评估脑供血对临床具有重要的指导意义.Objective To study Ihewdueof high resolution MRI（HRMRI） and MR perfusion weightedimaging（PWI） inevalua ring the middle cerebral artery（MCA） stenosis degree and the brian blood supply. Methods PWI was performed in 30 patients with unilateral stenosis of MCA was diagnosed by HRMRI. The cerebral perfusion parameters including regional cerebral blood volume （rCBV） ,regional cerebral blood flow（rCBF） ,regional mean transit time（rMTT） and regional time to peak（rTTP） of the both cerebral hemispheres were quantitatively analysed. Results Among 30 patients, the MCA stenosis diagnosed by HRMRI as mild in 7, moderate in 9 and severe or acclusion in 14, respectively. Abnormal perfusion presented in all cases. The perfusion parameters （rCBF, rMTT and rTTP） had statislical significance. Between the rate of MCA moderate stenosis, severe stenosis or occlusion and the in crease rate of rMTT showed a positive correlation（r= 0. 897 and 0. 829 respectively,P〈0.0l ）. Conclusion There is significantly value in evaluation of the MCA stenosis degree hy HRMRI, which in comhinntion wilh PWI Io assess brain blood supply is of impor rant value for clinic.

关 键 词：脑 磁共振成像 大脑中动脉 脑缺血 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742[医药卫生—诊断学]