兔正常及激素坏死股骨头的CT灌注成像研究  

Study of CT perfusion on normal femoral head and steroid-induced avascular necrosis of the femoral head in rabbits

作　　者：刘秀娟[1] 孙娜[1] 段岩松[2] 徐艳[3] 

机构地区：[1]哈尔滨医科大学附属第一医院CT室,黑龙江哈尔滨150001 [2]黑龙江省中医研究院南岗分院影像科 [3]哈尔滨医科大学附属第四医院影像科

出　　处：《实用放射学杂志》2012年第4期609-611,617,共4页Journal of Practical Radiology

基　　金：黑龙江省自然科学基金面上项目（D2007-47）.

摘　　要：目的 分析正常股骨头及激素坏死股骨头（SANFH）的CT灌注表现.方法 将30只实验兔随机分为2组,实验组25只,每周2次注射氢化可的松及青霉素;对照组5只,仅注射青霉素.用药后2、4、6、8、10周行CT灌注扫描,绘出股骨头的时间-密度曲线,分析其血流量（BF）、血容量（BV）及平均通过时间（MTT）灌注值.灌注后处死兔子,取其股骨头做病理切片.结果 正常兔两侧股骨头灌注曲线相近;正常股骨头与对照组股骨头灌注曲线亦相近,二者间的BF、BV及MTT无明显差异.在给药后2周、4周,BF、BV开始下降; 6周、8周,BF、BV明显下降; 10周,BF、BV不降反升.给药各时间段MTT变化不明显.结论 CT灌注能够较全面反映早期SANFH的血供变化.Objective To analyze CT perfusion imaging of normal femoral head and steroid induced avascular necrosis of the fern oral head （SANFH） in rabbits. Methods 30 rabbits were randomly divided into two groups. The experimental group was injected with hydrocortisone and penicillin twice a weeks, the control group was only injected with penicillin. At the time of 2, 4, 6, 8 and 10 weeks after injection, the experimenlal group and the control group underwent CT perfusion scan, respectively. Time-density curves（T DC） were depicted and the values of blood flow（BF）,Mood volume（BV） and mean transit time（MTT） of femoral heads were analysed. Rabbits were killed after perfusion and the fenmral heads of them were taken for pathologic examinations. Results The perfusion curves were similar between bilateral normal femoral heads,between the normal femoral head and the ones of control group,even the values of BF, BVand MTT were no of significant difference. BFand BVof femoral head began decrease duringearli er period （second week, fourth week） , obviously with prolongation of injection （sixth week, eighth week）. But BF and BV increased at tenth week. MTT had not an obvious change at diffcrenl time. Conclusion CT can reflect the blood changes of SANFH in early stage.

关 键 词：股骨头坏死 激素 体层摄影术 X线计算机 兔 实验 

分 类 号：R681.8[医药卫生—骨科学] R814.42[医药卫生—外科学]