牛病毒性腹泻病毒侵染细胞机制的研究进展  

Research Advances in Invasion Mechanism of Bovine Viral Diarrhea Virus

作　　者：宫晓炜[1] 郑福英[1] 蔺国珍[1] 曹小安[1] 王光华[1] 殷宏[1] 周继章[1] 才学鹏[1] 

机构地区：[1]中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室农业部兽医公共卫生重点开放实验室,兰州730046

出　　处：《畜牧兽医学报》2012年第4期503-508,共6页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家肉牛产业技术体系项目(CARS-38);家畜疫病病原生物学国家重点实验室基金项目(2011)

摘　　要：牛病毒性腹泻病毒(BVDV)是反刍动物和猪体内广泛存在的危害动物健康的重要病原体。BVDV感染牛后主要引起牛的持续性感染、免疫耐受、免疫抑制、繁殖障碍及急慢性黏膜病等临床症状,给养牛业造成重大的损失。其致病机理非常复杂,给该病的治疗和根除带来极大的困难。随着分子病毒学研究的发展以及对猪瘟病毒和黄病毒科其他成员的研究,人们在BVDV分子水平和细胞水平的研究方面也取得了一些进展。就此,作者从BVDV入侵细胞、在细胞内的复制以及与宿主蛋白分子相互作用等方面进行综述,有助于阐明BVDV致病和在体内持续存活的机制,为该病的防治和疫苗研发提供新的思路和对策。Bovine viral diarrhea virus（BVDV） is recognized as one of the important pathogens of ruminant and swine.BVDV causes a series of clinical symptoms of persistent infection,immunosuppression,reproductive disorders and acute or chronic mucosal disease（MD）.The disease impacts the economic development of cattle industry.It is difficult to treat and eradicate the disease from cattle because of the complex pathogenesis.With the development of molecular virology of classical swine fever virus and other members of the Flaviviridae,some achievements have been obtained about the research on BVDV,particularly at the cellular and molecular levels.In this paper,the pathogenesis and persistent infection of BVDV are explained,through review the mechanism of BVDV invasion cell,replication and interaction with host cell.It gives some new ideas for vaccine research and control strategy of bovine viral diarrhea（BVD）.

关 键 词：牛病毒性腹泻病毒 病毒复制 宿主细胞 相互作用 

分 类 号：S852.659.6[农业科学—基础兽医学]