4-羟基-2-吡啶酮类化合物的合成研究进展  

Progress in the Synthesis of 4-Hydroxy-2-pyridone Derivatives

作　　者：赵圣印[1] 黄婧[1] 程健[1] 刘宝硕[1] 陈晨[1] 

机构地区：[1]东华大学化学化工与生物工程学院,上海201620

出　　处：《有机化学》2012年第4期651-660,共10页Chinese Journal of Organic Chemistry

基　　金：上海市自然科学基金(No.10ZR1400700);国家自然科学基金(No.21072029)资助项目~~

摘　　要：4-羟基-2-吡啶酮是天然生物碱结构母核,同时也是一类重要的医药中间体,该类衍生物具有抗真菌、抗菌和抗肿瘤等多种生物活性.因此,其合成得到了广泛的研究和关注.综述了近年来4-羟基-2-吡啶酮类化合物的合成方法及其研究进展.4-Hydroxy-2-pyridones are embedded as common structural units of many natural products,which exhibited good or excellent biological activities such as antifungal,antibacterial,and cytototoxic activity and so on.The class of compounds has stimulated a great deal of interest on synthetic chemists due to their structural novelty,molecular diversity,and promising biological activities.In this paper,the recent progress in the synthesis of 4-hydroxy-2-pyridones has been reviewed.

关 键 词：4-羟基-2-吡啶酮 合成 研究进展 

分 类 号：TQ463.54[化学工程—制药化工]