无催化剂微波促进下C-O,C-N和C-S交叉偶联反应研究  

Rapid and Highly Efficient Microwave-Assisted C—N, C—O and C—S Coupling Reactions without a Transition-Metal Catalyst

作　　者：袁艳琴[1] 郭圣荣[1] 莫建军[1] 钱利[1] 石泽凤[1] 

机构地区：[1]丽水学院化学化工系,丽水323000

出　　处：《有机化学》2012年第4期732-741,共10页Chinese Journal of Organic Chemistry

基　　金：浙江省自然科学基金基金(No.Y407240);丽水学院重点科研(No.KZ20H03)资助项目~~

摘　　要：在无金属催化剂的条件下,利用微波加热促进C—O,C—N和C—S交叉偶联反应.实验发现以DMSO为溶剂,t-BuOK为碱,利用微波加热,活化的氯代芳烃能与各类亲核试剂顺利反应,得到中等及优良的产率.A rapid and direct coupling reactions of various N/O/S nucleophilic reagents with aryl halides have been developed in good to high yields under microwave irradiation without a transition-metal catalyst.These reactions are a particularly powerful method for the coupling of electron-withdraw aryl halides with various nucleophilic reagents.A variety of products including aryl ethers,N-arylamides,and aryl thioethers were synthesized in good to excellent yields.

关 键 词：微波 交叉偶联反应 芳基醚 芳基硫醚 N-芳基化 

分 类 号：O621.25[理学—有机化学]