长春新碱联合小剂量环磷酰胺治疗系统性红斑狼疮的安全性及对BAFF的影响  

作　　者：彭肖[1] 张莉芸[2,3] 李小峰[1] 乔鹏燕[1] 陈俊伟[1] 罗静[1] 张辰[1] 

机构地区：[1]山西医科大学第二医院风湿免疫科,太原030001 [2]山西医学科学院 [3]山西大医院风湿免疫科

出　　处：《中国医疗前沿》2012年第6期1-2,25,共3页China Healthcare Innovation

摘　　要：目的研究长春新碱(VCR)联合小剂量环磷酰胺(CTX)治疗系统性红斑狼疮(SLE)的安全性和对B细胞活化因子(BAFF)mRNA表达水平的影响。方法进行12周随机、对照研究,将纳入的SLE患者分为大剂量CTX组、VCR联合小剂量CTX、VCR联合大剂量三组,观察用药期间发生的不良事件,实时荧光定量RT-PCR检测BAFF mRNA表达水平。结果⑴VCR联合小剂量CTX组不良事件发生率与大剂量CTX组、VCR联合大剂量CTX组差异无统计学意义;⑵在基线时、12周时,VCR联合小剂量CTX组BAFF mRNA表达水平与大剂量CTX组、VCR联合大剂量CTX比较差异无统计学意义;⑶三组治疗前后BAFF mRNA表达水平明显下降,差异有统计学意义(P<0.05)。结论 VCR联合小剂量CTX治疗SLE疗效确切,副作用无明显增加。Objective we aimed to study the safety of VCR combined CTX treating SLE and the influence on BAFF mRNA.Methods Conducted a 12-week randomized,controlled study.Included in the study of SLE patients were divided into single with cyclophosphamide,VCR and low dose CTX,VCR and high dose CTX group.Observe the side effect.Real-time quantitative RT-PCR detect peripheral blood mononuclear cells in BAFF expression.Results ⑴Compared with CTX,VCR and high CTX group,the VCR and low CTX group,side effects has no different.⑵BAFF mRNA has no different.⑶BAFF mRNA levels decreased obviously after treatment.Conclusion Vincristine and low dose cyclophosphamide treatment group can significantly improve the condition and less side effect.

关 键 词：系统性红斑狼疮 长春新碱 环磷酰胺 BAFF 

分 类 号：R593.24[医药卫生—内科学]