上海市闵行区新生儿出生缺陷的危险因素  

Risk Factors of Birth Defects in Minhang District of Shanghai

作　　者：应圣洁[1] 赵乾魁[1] 张鑫毅[1] 田秀红[1] 丁克颖[1] 

机构地区：[1]上海市闵行区疾病预防控制中心,上海201101

出　　处：《环境与职业医学》2012年第4期206-209,共4页Journal of Environmental and Occupational Medicine

基　　金：上海市闵行区自然科学基金(编号:2010MHZ047)

摘　　要：[目的]了解影响上海市闵行区新生儿出生缺陷的主要危险因素。[方法]采用病例-对照研究的方法,制定统一调查表,通过上门访谈或通知被调查者来访的方式进行流行病学问卷调查。[结果]单因素logistic回归分析结果显示,孕妇职业、家庭人均收入、历次新生子女出生缺陷、双胎或多胎、孕期易缺乏营养素的补充情况、孕期严重影响情绪事件、孕前配偶饮酒情况、居室装修后入住时间这8个因素与新生儿缺陷的发生有关(P<0.05)。将筛选出的8个危险因素作二分类多因素logistic回归分析,最终进入模型的变量为孕期有无严重影响情绪事件和历次新生子女有无出生缺陷。[结论]新生儿缺陷的发生与多种因素有关,应采取有针对性的干预措施减少或避免有关危险因素,降低新生儿出生缺陷发生率。[Objective] To investigate the risk factors which have effects on birth defects in Minhang District of Shanghai.[Methods] A case-control study was conducted by either home visit or informing the respondents to come to accept unified epidemiological investigations.[Results] The results of univariate logistic regression analysis showed that the occurrence of birth defects was correlated with 8 factors including maternal occupation,per capita household income,previous history of birth defects,twins or multiple births,supplement of essential nutrients during pregnancy,severe emotional events,husband＇s drinking habits before wife＇s pregnancy,and time to move in a house after decoration（P 0.05）.Multivariate logistic regression analysis showed that severe emotional events and previous history of birth defects entered the model.[Conclusion] The occurrence of birth defects is associated with many factors.Targeted measures against these risk factors could be effective in reducing the incidence of birth defects.

关 键 词：出生缺陷 危险因素 病例对照 

分 类 号：R272.1[医药卫生—中医儿科学]