栀子金花分散片的制备  

Preparation of Zhizijinhua dispersible tablets

作　　者：赵文普[1] 崔英慧 刘喜纲[1] 刘翠哲[1] 

机构地区：[1]河北省中药研究与开发重点实验室/承德医学院中药研究所,河北承德067000 [2]河北省隆化县医院药剂科,河北承德068150

出　　处：《中国医院药学杂志》2012年第8期584-587,共4页Chinese Journal of Hospital Pharmacy

基　　金：承德市科学技术研究与发展计划项目(编号:201021020)

摘　　要：目的:研究栀子金花分散片的制备工艺。方法:采用粉末直接压片法,以崩解时限和分散均匀度为指标进行单因素考查,筛选适宜的辅料及其用量,并用HPLC法测定栀子苷的溶出度。结果:优选处方在3 min内崩解并通过2号筛,45 min时药物溶出86.6%,符合分散片的各项评价指标。结论:制备的栀子金花分散片符合要求,可为生产提供依据。OBJECTIVE To investigate the preparation method of Zhizijinhua dispersible tablets. METHODS Powder direct compression method was used to prepare the tablets. The method was optimized by using single factor for disintegration time and dispersion uniformity to choose the suitable disintegrants, fillers and lubricants. The dissolution rate of geniposide was determined by HPLC. RESULTS The optimized prescription of tablets was disintegarated within 3 minutes and the dissolution rate was above 86. 6% at 45 min. CONCLUSION The preparation of Zhizijinhua dispersible tablets accords with the requirements, and can provide experimental basis for manufacture.

关 键 词：栀子金花分散片 栀子苷 HPLC 

分 类 号：R285.5[医药卫生—中药学]