孕产妇血清中p,p’-DDE暴露水平及其影响因素  

Influencing Factors of p,p'-DDE Exposure in Pregnant Women in a City

作　　者：刘迎春[1] 李成橙[1] 康家琦[1] 林少斌[1] 金银龙[1] 程义斌[1] 

机构地区：[1]中国疾病预防控制中心环境与健康相关产品安全所,北京100050

出　　处：《环境与健康杂志》2012年第4期297-299,共3页Journal of Environment and Health

基　　金：十一五"国家科技支撑项目(2006BAI19B01)

摘　　要：目的研究孕产妇血清中p,p’-DDE暴露水平并对其影响因素进行分析。方法于2010年选择某市一所医院妇产科的300名孕产妇作为研究对象,测定孕产妇静脉血清中p,p’-DDE的含量,并对相关影响因素开展问卷调查。结果p,p’-DDE在孕产妇血清中的检出率为89.47%(221/247),Speaman分析表明孕产妇BMI和年龄与其静脉血清中p,p’-DDE的含量呈正相关,且差异有统计学意义(P<0.05);多因素分析结果提示:孕产妇的年龄每增加1岁和体质指数(BMI)每增加1 kg/m2,孕妇血清中p,p’-DDE的含量分别相应增加29.01 ng/g(以脂计)和23.73 ng/g(以脂计),有妊娠史的孕产妇比无妊娠史的孕产妇静脉血中p,p’-DDE的含量低161.64 ng/g(以脂计)。结论孕产妇年龄的增加及BMI的增高可能会导致静脉血清中p,p’-DDE暴露水平的升高;有妊娠史的孕产妇血清中的p,p’-DDE含量可能较无妊娠史的孕产妇低。Objective To know the exposure level of p ,p＇-DDE in pregnant women and the influencing factors. Methods A total of 300 pregnant women were investigated in a hospital. The contents of p ,p＇ -DDE in the peripheral serum of pregnant women were determined and questionnaire survey on related factors was conducted. Results The detection rate of p ,p＇-DDE in peripheral serum of pregnant women was 89.47%（221/247）. Spearman correlation analysis showed that body mass index （BMI） and age had positive correlation with p ,p ＇-DDE （P〈0.05）. Multiply linear regression model results showed that age, BMI and pregnancy history were the independent factors for the p ,p ＇-DDE level after eontrolling the other confounders. Conclusion With the increase of age and BMI, the content of p ,p＇ -DDE in the peripheral serum also increase. Pregnant women have a lower content ofp ,p ＇-DDE than primipara.

关 键 词：农药 孕产妇 血清 p p'-DDE 暴露水平 

分 类 号：R181.3[医药卫生—流行病学]