一种近红外光响应的温敏性纳米载药系统的研究  

A novel thermo-sensitive nano drug-delivery system triggered by near-infrared light

作　　者：迟雪梅[1] 崔思思[1] 曹洁[1] 田俊梅[1] 顾月清[1] 

机构地区：[1]中国药科大学生物医学工程教研室,南京210009

出　　处：《中国药科大学学报》2012年第2期147-153,共7页Journal of China Pharmaceutical University

摘　　要：采用晶种生长法,以十六烷基三甲基溴化铵(CTAB)作为软模板制备了长约50 nm、长径比为3.9的尺寸均一的用于近红外热疗的金纳米棒。通过静电层层组装(LbL)技术,将聚电解质和牛血清白蛋白组装到金纳米棒上,得到在水溶液中均匀分散的功能化温敏性纳米载药体系,同时利用基团之间静电作用力使带正电荷的小分子抗肿瘤药物盐酸阿霉素嵌合在该多功能的运载系统中。在近红外激光照射下,金纳米棒吸收光能转化成的热能使高聚物崩解,导致阿霉素从系统中释放出来,从而达到光热疗法与化疗方法联合治疗肿瘤的目的。In this paper,gold nanorods with aspect ratio of 3.9 and a longitudinal absorbance peak at 765 nm were prepared using seed-mediated method in which the cationic surfactant cetyltrimethylammonium bromide（CTAB） was used as a soft template and structure-guiding agent.By using layer-by-layer technique,polyelectrolytes and bovine serum albumin were assembled to the gold nanorods to form a functional thermo-sensitive nano drug-delivery system,dispersed uniformly in the aqueous solution.Meanwhile,the small molecular cationic drug,doxorubicin（Dox）,was encapsulated into the nanocarriers（Au-NRs/Dox@PE） by electrostatic force.Upon near-infrared（NIR） light irradiation,gold nanorods absorbed NIR light and converse it into heat,resulted in the disintegration of the polyelectrolytes and the photothermal controlled release of Dox,which combined photothermal therapy and chemotherapy for cancer treatment.

关 键 词：金纳米棒(Au-NRs) 聚电解质 近红外热疗 温敏纳米控释系统 

分 类 号：R943[医药卫生—药剂学]