两面针与毛两面针药材中5种化学成分的比较研究  

Comparative studies of five chemical constituents in Zanthoxylum nitidum(Roxb.) DC. and Z.nitidum(Roxb.) DC.f.fastuosum How ex Huang

作　　者：黄琪[1,2] 雷鹏[1,2] 李秀杰[1,2] 叶倩[1,2] 尹桃[1,2] 林琼丽[1] 

机构地区：[1]中南大学湘雅医院药剂科,长沙410008 [2]中南大学药学院,长沙410013

出　　处：《中国药科大学学报》2012年第2期154-158,共5页Journal of China Pharmaceutical University

基　　金：湖南省中医药科技基金重点课题资助项目(No.2009008);长沙市科技局重点项目资助(No.K0802115-31)~~

摘　　要：通过建立RP-HPLC法同时测定两面针与毛两面针中木兰花碱、橙皮苷、氯化两面针碱、乙氧基白屈菜红碱及毛两面针素含量,对市场收集到的27批两面针商品药材以及2批野生药材进行分析,比较两者间各成分及含量上的差异。结果表明两面针与毛两面针5种成分差异较大:前者中主要含生物碱成分,其中乙氧基白屈菜红碱含量较高;后者中均含有这5种成分,毛两面针素、橙皮苷所占含量比重较大;且相同品种间各成分也存在一定的差异。该结果可为两者的质量控制、合理用药及进一步研究开发提供参考。This present study applied the RP-HPLC method to determine the contents of the five main chemical constituents in Z.nitidum（Roxb.） DC.and Z.nitidum（Roxb.） DC.f.fastuosum How ex Huang simultaneously,including magnoflorine,hesperidin,nitidine chloride,ethoxychelerythrine and toddaloactone,and fastuosum.The composition and contents in 27 batches of Z.nitidum（Roxb.） DC.collected in the market and 2 batches of wild herbs were analyzed to investigate their differences.Results showed that the five constituents in the two herbs are quite different.The former mainly contained magnoflorine,nitidine chloride and ethoxychelerythrine;while the latter contained all the five components,especially the contents of toddaloactone and hesperidin are much higher.Besides,the content diffe-rences of the constituents between the different batchs of the same herb are existed.The test result may provide a reference for the rational usage,quality control and further study of the herbs.

关 键 词：反相高效液相色谱法 两面针 毛两面针 含量测定 比较研究 

分 类 号：R284.1[医药卫生—中药学]