Rho/ROCK通路与NADPH氧化酶在糖尿病肾病中的作用  

Role of Rho/ROCK pathway and NADPH oxidase in the pathogenesis of diabetic nephropathy

作　　者：张育茂[1] 戴德哉[1] 于锋[1] 戴茵[1] 

机构地区：[1]中国药科大学药理学研究室,南京210009

出　　处：《中国药科大学学报》2012年第2期187-192,共6页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.81070145)~~

摘　　要：Rho/ROCK通路与NADPH氧化酶的激活,都能够促进糖尿病肾病的发生发展。Rho/ROCK通路与NADPH氧化酶可能也存在着某些联系,研究二者之间的关系与相关机制,对发现治疗糖尿病肾病的新药可能具有重要的意义。本文首先介绍了Rho/ROCK通路与NADPH氧化酶及二者的激活因素,然后总结了二者在糖尿病肾病中对肾脏血流动力学、滤过功能以及肾内基质的影响,最后简要介绍了与二者相关的糖尿病肾病药物治疗靶点。The activation of Rho/ROCK pathway and NADPH oxidase play a vital role in the development of diabetic nephropathy.There may be some connections between Rho/ROCK pathway and NOX.The exploration of the mechanisms underlying may be beneficial to the discovery of novel therapy for diabetic nephropathy.Herein,the Rho/ROCK pathway and NADPH oxidase are introduced as well as their stimulus.Further more,their impact on the renal hemodynamic,filtration function and remodeling of extracellular matrix in the process of diabetic nephropathy are described.Some potential targets in diabetic nephropathy associated with Rho/ROCK pathway and NADPH oxidase are also presented.

关 键 词：RHO激酶 糖尿病肾病 还原型辅酶Ⅱ氧化酶 氧化应激 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]