鸡枞多糖对急性感染小鼠的WBC、C3、CRP和IgM变化研究  

Effect of collybia albuminosa polysacchorrides on WBC,WBC,C3,CRP and IgM in acute infection mice model

作　　者：冯宁[1] 吴海婴 左方财 陈光明[1] 吴世木 张元礼 

机构地区：[1]贵州省兴义市人民医院检验医学科,562400 [2]贵州省黔西南州人民医院药剂科,562400

出　　处：《国际检验医学杂志》2012年第8期902-903,共2页International Journal of Laboratory Medicine

基　　金：贵州省黔西南州重点科研项目(编号2006-47)

摘　　要：目的探讨鸡枞多糖对急性感染性小鼠的白细胞(WBC)、补体(C3)、C反应蛋白(CRP)和免疫球蛋白(IgM)水平变化。方法取一定浓度的大肠埃希菌(0.3麦氏单位)对分组小鼠腹腔进行接种,1d后以庆大霉素(最小抑菌浓度)和庆大霉素+鸡枞多糖进行腹腔注射治疗,3d后及7d后对分组小鼠进行眼球取血,检测其WBC、CRP、C3、IgM水平变化。结果庆大霉素组与庆大霉素+鸡枞多糖组比较,WBC、C3、CRP、IGM差异均有统计学意义(P<0.05)。结论鸡枞多糖能使机体免疫反应处于一个相对较低的稳定状态,可避免因过度剧烈的免疫反应而导致免疫损伤。Objective To evaluate the effect of collybia albuminosa polysacchorrides on white blood cell counts（WBC） ,complement C3（C3） ,C reaction protein（CRP） and immunoglobulin M（IgM） in mice model of acute infection.Methods Escherichia coli（E.coli） of 0.3 McFarland Standard Unit were intraperitoneally inoculated into divided groups.Single Gentamicin,with concentration of minimum inhibitory concentration,or Gentamicin＋polysaccharides were intraperitoneally injected 1 day after for therapy.3 and 7 days after inoculation,blood from eyeball of different groups of mice were collected and,and detected for WBC,C3,CRP and IgM.Results The single Gentamicin group was significant statistical difference from the single Gentamicin＋polysaccharides group with the WBC,C3,CRP and IgM（P0.05） .Conclusion Collybia albuminosa polysaccharides could cause low stable immunoreaction at relatively low degree and avoid immunologic injury caused by vigorous immunoreaction.

关 键 词：鸡枞多糖 小鼠 白细胞 补体C3 

分 类 号：R285.5[医药卫生—中药学]