外周血胎盘蛋白-13、胎盘生长因子等指标预测子痫前期的临床价值  

Clinical value of serum placental protein-13 and placental growth factor for the risk assessment of preeclampsia during the first trimester of pregnancy

作　　者：钱雷[1] 吴凤会[1] 徐敏[2] 汪晓莺[2] 

机构地区：[1]江苏省滨海县人民医院检验科,224500 [2]南通大学免疫学教研室,江苏南通226001

出　　处：《国际检验医学杂志》2012年第8期907-909,共3页International Journal of Laboratory Medicine

基　　金：江苏高校优势学科建设工程资助项目(PAPD)

摘　　要：目的分析血管内皮生长因子(VEGF)165b、胎盘蛋白-13(PP-13)、胎盘生长因子(PIGF)、可溶性CD105淋巴细胞抗原(sEng)和可溶性血管内皮生长因子受体-1(sFlt-1)在子痫前期(PE)患者孕早期血清中的表达,探讨其预测PE发生的临床意义。方法收集67例无高血压健康孕妇和65例PE孕妇9～10周的外周血,采用ELISA法检测血清PP-13、PIGF、VEGF165b、sEng和sFlt-1的浓度。使用ROC曲线分析VEGF165b、PP-13和PIGF预测PE发生的灵敏度和特异性。结果孕妇孕9～10周,PE患者的外周血与健康孕妇比较,PP-13[(50.20±31.20)与(108.7±51.2)pg/mL]、PIGF[(58.64±18.01)与(86.19±16.78)pg/mL]、VEGF165b[(1.27±0.41)与(2.03±0.75)ng/mL],差异有统计学意义(P<0.05);sEng和sFlt-1差异无统计学意义(P>0.05)。ROC曲线结果显示孕9～10周,PP-13、PIGF中值倍(MoM)之和预测PE的发生,具有较高的灵敏度(96.0%)和特异性(96.3%)。结论孕早期联合检测PP-13、PIGF等指标对预测PE的发生有较好的临床价值。Objective To evaluate the signification of serum vascular endothelial growth factor（VEGF） 165b,placental protein-13（PP-13） ,placental growth factor（PIGF） soluble,soluble endoglin（sEng） and fms-like tyrosine kinase1（sFlt-1） for predicting risk of preeclampsia（PE） during the first trimester of pregnancy.Methods 65 cases of gravida with PE and 67 cases of healthy gravida without hypertension were enrolled and detected for serum level of PP-13、PIGF、VEGF165b、sEng and sFlt-1 during 9-10 weeks of gestation.The sensitivity and specificity of VEGF165b、PP-13 and PIGFR for the prediction of PE were analyzed through receiver operating characteristic（ROC） curve.Results During 9-10 weeks of gestation,serum levels of PP-13,PIGF and VEGF165b of gravida with PE were（50.20±31.2） pg/mL,（58.64±18.01） pg/mL and（1.27±0.41） ng/mL,which were significantly different with（108.7±51.2） pg/mL,（86.19±16.78） pg/mL and（2.03±0.75） ng/mL of healthy gravida（P0.01） ,but there was no statistical difference of sEng and sFlt-1（P0.05） .ROC curve indicated that the sum of multiple of the median（MoM） of serum PP-13 and PIGF level during the first trimester were with sensitively of 96.0% and specificity of 96.3% for predicting the risk of PE.Conclusion Combined detection of PP-13,PIGF and other serum markers might be with fine clinical value for detecting PE.

关 键 词：先兆子痫 胎盘蛋白-13 胎盘生长因子 妊娠子 

分 类 号：R714.245[医药卫生—妇产科学]