三七止血与抗血栓作用的实验研究  

Hemostatic and anti-thrombosis effects study of Radix Panax Notoginseng

作　　者：张海英[1] 盛树东[2] 薛洁[3] 

机构地区：[1]新疆医科大学附属中医医院药学部,乌鲁木齐830000 [2]扬州环境资源职业技术学院,江苏扬州225127 [3]新疆医科大学科研处,乌鲁木齐830011

出　　处：《新疆医科大学学报》2012年第4期487-490,共4页Journal of Xinjiang Medical University

基　　金：新疆维吾尔自治区科技攻关和重点科技项目(200233106);新疆医科大学大学生创新性实验计划项目(CX2010031)

摘　　要：目的研究中药三七的止血与抗血栓作用。方法将小鼠随机分为5组(对照组、云南白药组、三七低、中、高剂量组),每组12只。给药组以三七0.46、0.91、1.82g/kg剂量灌胃,应用毛细管法、剪尾法测定小鼠的凝血时间、出血时间,观察三七对小鼠的止血作用;将Wistar大鼠随机分为5组(对照组、阿司匹林组、三七低、中、高剂量组),每组8只。给药组以三七0.32、0.63、1.26g/kg剂量灌胃,应用动、静脉旁路丝线血栓形成法,以血栓湿重、血栓抑制率为指标,观察三七对大鼠体内血栓形成的影响。结果与正常对照组相比,三七低剂量组可缩短凝血时间、出血时间(P<0.05);与正常对照组相比,三七中、高剂量组血栓湿重明显降低,血栓抑制率明显上升(P<0.05)。结论三七低剂量具有一定的止血作用,中、高剂量具有抗血栓形成作用,其机制可能为抑制血小板聚集。Objective To study the hemostatic and anti-thrombosis effects of Radix Panax Notoginseng.Methods KM mice were randomly divided into 5 groups：normal group,Yun-nan-bao-yao Capsule group,Radix Panax Notoginseng high,middium,low dosage groups,12 mice in each group.The test groups were administrated with Radix Panax Notoginseng by 0.46,0.91,1.82 g/kg respectively.Bleeding time and coagulation time were measured to observe the hemostatic effects.Wistar rats were randomly divided into 5 groups：normal group,Aspirin Tablet group,Radix Panax Notoginseng high,middium,low dosage groups,8 rats in each group.The test groups were administrated with Radix Panax Notoginseng by 0.32,0.63,1.26 g/kg respectively.Used the methods of artery-vein bypass thrombus form to observe the anti-thrombosis effects.Results Compared with normal group,low dose of Radix Panax Notoginseng could reduce the Bleeding time and coagulation time of mice（P0.05）.Middium and high dose of Radix Panax Notoginseng could obviously reduce thrombus weight（P0.05）.Conclusion Radix Panax Notoginseng has hemostatic and anti-thrombosis effects.Its mechanism is probably for inhibiting platelet aggregation.

关 键 词：三七 止血 抗血栓 

分 类 号：R965[医药卫生—药理学]