新生儿窒息血清IL-6和TNF-α动态监测的临床价值  

Clinical value of dynamic monitoring neonatal asphyxia on serum IL-6 and TNF-α

作　　者：蔡兰富[1] 陈金春[2] 陈海斌[2] 谢江强 郑俊火 杜文君[1] 

机构地区：[1]浙江省瑞安市人民医院儿科,浙江瑞安325200 [2]浙江省瑞安市人民医院体检中心,浙江瑞安325200

出　　处：《中国现代医生》2012年第12期57-58,共2页China Modern Doctor

基　　金：浙江省瑞安市2009年第四批科技计划项目(20094027)

摘　　要：目的研究窒息新生儿血清IL-6和TNF-α动态监测的临床价值。方法选择符合诊断标准的新生儿窒息患者37例,分别于生后30 min和1、3、5、7 d,观察Apgar评分、血清IL-6、TNF-α的变化,并进行统计学分析。结果患儿出生后30 min、1、3、5、7 d Apgar评分、血清IL-6、TNF-α分别为3.66±1.67、6.04±0.57、6.61±0.84、7.52±0.91、9.16±0.62和153.9±20.9、120.6±16.4、104.2±13.7、81.4±11.8、65.8±9.1和193.9±25.1、155.3±19.8、132.3±16.1、119.7±13.9、94.3±11.5,相互比较差异显著(P<0.05)。结论新生儿窒息患儿动态监测血清IL-6、TNF-α的变化对其预后的评估具有重要的临床价值。Objective To study the clinical value of dynamic monitoring neonatal asphyxia on serum IL-6 and TNF-α. Methods Chose 37 cases in the neonatal asphyxia patients who met the diagnostic criteria, then respectively, in the 30 min after birth and 1, 3, 5, 7 d, Apgar scores, serum IL-6 and TNF-α changes were observed , and finally the statistical analysis was made. Results The value was respectively 3.66＋ 1.67, 6.04 ±0.57,6.61 ±0.84, 7.52±0.91, 9.16 ±0.62, 153.9 ±20.9, 120.6±16.4,104.2±13.7,81.4±11.8,65.8±9.1, 193.9±25.1, 155.3±19.8, 132.3±16.1, 119.7±13.9, 94.3±11.5. The difference between them was great （P 〈 0.05）. Conclusion Dynamic monitoring neonatal asphyxia on serum IL-6 and TNF-α changes have important clinical value for its prognostic assessment.

关 键 词：新生儿窒息 IL-6 TNF-Α 

分 类 号：R722.120.2[医药卫生—儿科]