不同剂量小檗碱对大鼠梗死后心肌组织的保护作用  

The protective effect of berberine with different doses on the myocardial infarction in rats

作　　者：丁世豪[1] 李真真[1] 王石雄[1] 卢俊阳[1] 高秉仁[1] 

机构地区：[1]兰州大学第二医院心脏外科,兰州730030

出　　处：《重庆医科大学学报》2011年第10期1205-1208,共4页Journal of Chongqing Medical University

摘　　要：目的:对心肌梗死后大鼠灌胃不同剂量小檗碱,探讨小檗碱对大鼠梗死后心肌组织的保护作用和对梗死后心功能的影响。方法:开胸结扎冠脉方法制作大鼠心梗模型,模型建立成功后持续灌胃5 d,每天灌胃1次,末次灌胃后测量相关心功能参数,随后处死大鼠做心肌形态学和血清酶学分析。结果:小檗碱可以改善梗死后心脏的心功能,减小心肌缺血范围和梗死范围,减少心肌乳酸脱氢酶(Lactate dehydrogenase,LDH)的释放。不同剂量小檗碱的心肌保护作用有所差异。结论:小檗碱对大鼠梗死后心肌组织有明显保护作用,能明显改善心功能,且其这种作用随剂量的不同有统计学差异。Objective：To investigate the protective effects of different doses of berberine（BBR） on the myocardial infarction and the cardiac function in rats by using different doses of BBR to drench the rats.Methods：The method of ligaturing coronary artery was used to set up the models of the myocardial infarction in the rats.After the operations,the different groups of the rats were drenched with different drugs and different doses for 5 days.After the last drench,the relevant parameters of the function were measured,and then samples of the hearts and blood were collected for analysis.Results：BBR improve the function of the rats and the infarct and the ischemia sizes.It also decrease the level of LDH.The results of the groups of different doses had significant difference.Conclusion： BBR can significantly protect the heart after infarction and improve the heart function.The ability varies with different doses.

关 键 词：小檗碱 心肌梗死 心肌保护 

分 类 号：R654.2[医药卫生—外科学]