透明质酸钠联合复方倍他米松关节腔注射治疗膝骨关节炎临床研究  

Efficacy of intra-articular injection of combination of sodium hyaluronate and compound Betamethasone in the treatment of knee osteoarthritis

作　　者：张鹏[1] 张金玲 雍玉玺 徐新玉[1] 柴霞[1] 吐苏娜依[1] 

机构地区：[1]兰州军区乌鲁木齐总医院中医科,新疆乌鲁木齐830000 [2]喀什地区人民医院特检科 [3]乌鲁木齐新市区联建社区卫生服务站

出　　处：《西北国防医学杂志》2011年第6期448-451,共4页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的:观察和评价透明质酸钠联合复方倍他米松关节腔注射治疗膝骨关节炎的临床疗效和安全性。方法:将110例膝骨关节炎患者随机分为试验组、对照组各55例,采用随机单盲、同期对照法,两组膝关节腔均注入透明质酸钠注射液20 mg,每周1次,连续5次,两组首次分别加注复方倍他米松注射液1 ml、生理盐水1 ml。结果:两组治疗后Lequence评分、血清NO、IL-1β含量均下降,与治疗前比较,差异有统计学意义(P<0.05),试验组下降较对照组明显,差异有统计学意义(P<0.05);两组总有效率分别为98.2%和78.2%,疗效差异有统计学意义(P<0.05),试验组疗效优于对照组。两组不良反应发生率差异无统计学意义(P>0.05)。结论:透明质酸钠联合复方倍他米松关节腔注射治疗膝骨关节炎疗效优于单用透明质酸钠,不良反应发生率小,安全可靠。Objective：To investigate the effect of the combination of sodium hyaluronate and compound Betamethasone in the treatment of knee osteoarthritis.Methods：A total of 110 cases of osteoarthritis of the knee were randomly and single-blinded divided into two groups,including 55 cases in combined experimental group,who were treated with the injection into knee articular cavity of 20 mg sodium hyaluronate once a week for a duration of 5 weeks,and on the first time of administration,1 ml compound Betamethasone was also injected combined with sodium hyaluronate.Another 55 cases in control group were treated with the same therapy but with the replacement of compound Betamethasone by saline.Results：Both of the Lequence indexes,blood serum NO and IL-1β of the two groups decreased compared with pre-therapy（P〈0.05）,while the data of experimental group decreased more significantoy（P〈0.05）.The overall effective rates of the two groups were 98.2% and 78.2%,respectively（P〈0.05）.There was no statistical difference between the two groups in the incidence of the side-effects.Conclusion：Intea-articular injection of combination of sodium hyaluronate and compound Betamethasone in the treatment of knee osteoarthritis has better therapeutic effect than the administration of sodium hyaluronate alone.

关 键 词：骨性关节炎 透明质酸钠 复方倍他米松 膝关节 

分 类 号：R684.3[医药卫生—骨科学]